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Copaiba Oil-Based Emulsion as a Natural Chemotherapeutic Agent for the Treatment of Bovine Mastitis: In Vivo Studies.
Campanholi, Katieli da Silva Souza; Junior, Ranulfo Combuca da Silva; Morais, Flávia Amanda Pedroso de; Gonçalves, Renato Sonchini; Rodrigues, Bruna Moura; Pozza, Magali Soares Dos Santos; Castro-Hoshino, Lidiane Vizioli de; Leite, Silvio Mayke; Capeloto, Otávio Augusto; Baesso, Mauro Luciano; Pozza, Paulo Cesar; Caetano, Wilker.
Afiliação
  • Campanholi KDSS; Chemistry Department, State University of Maringá, Maringá 87020-900, Brazil.
  • Junior RCDS; Chemistry Department, State University of Maringá, Maringá 87020-900, Brazil.
  • Morais FAP; Centre de Recherches sur les Macromolecules Végétales (CERMAV)-CNRS, Université Grenoble Alpes, 601, rue de la Chimie, BP 53, CEDEX 9, 38041 Grenoble, France.
  • Gonçalves RS; Laboratory of Chemistry of Natural Products, Department of Chemistry, Center for Exact Sciences and Technology, Federal University of Maranhão, São Luís 65080-805, Brazil.
  • Rodrigues BM; Animal Science Department, State University of Maringá, Maringá 87020-900, Brazil.
  • Pozza MSDS; Animal Science Department, State University of Maringá, Maringá 87020-900, Brazil.
  • Castro-Hoshino LV; Physics Department, State University of Maringá, Maringá 87020-900, Brazil.
  • Leite SM; Animal Science Department, State University of Maringá, Maringá 87020-900, Brazil.
  • Capeloto OA; Institute of Health and Biotechnology of Coari, Federal University of Amazonas, Coari 69460-000, Brazil.
  • Baesso ML; Physics Department, State University of Maringá, Maringá 87020-900, Brazil.
  • Pozza PC; Animal Science Department, State University of Maringá, Maringá 87020-900, Brazil.
  • Caetano W; Chemistry Department, State University of Maringá, Maringá 87020-900, Brazil.
Pharmaceutics ; 15(2)2023 Jan 20.
Article em En | MEDLINE | ID: mdl-36839669
ABSTRACT
Copaiba oil-resin (COR) extracted from Copaifera reticulata Ducke has been used as a natural chemotherapeutic agent for a wide range of therapeutic applications. This study presents an emulgel design with a high concentration of COR, designed to prevent and treat mastitis. The COR was stabilized in a gel matrix constituted by carbopol C934P and Pluronic® F127 (ECO formulation) ratios. The permeation study of ECO was accessed by Fourier transform infrared photoacoustic spectroscopy (FTIR-PAS). The results reveal a high capacity of ECO to permeate deep skin layers. Dairy cows with a history of mastitis were used as in vivo models and exposed to ECO treatment. Monitoring of the teat's inflammatory response showed that ECO effectively prevents mastitis. Furthermore, the ECO formulation was able to form a thin film gel on the application side, preventing fly proliferation and significantly reducing the pathogen load. This study reveals a drug that can used as an alternative application for mastitis in human or veterinary clinics.
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2023 Tipo de documento: Article
Texto completo
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XML
PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2023 Tipo de documento: Article