3D printed wound constructs for skin tissue engineering: A systematic review in experimental animal models.
J Biomed Mater Res B Appl Biomater
; 111(7): 1419-1433, 2023 07.
Article
em En
| MEDLINE
| ID: mdl-36840674
ABSTRACT
Wound dressings are one of the most used treatments for chronic wounds. Moreover, 3D printing has been emerging as a promising strategy for printing 3D printed wound constructs, being able of manufacturing multi layers, with a solid 3D structure. Although all these promising effects of 3D printed wound constructs, there is still few studies and limited understanding of the interaction of these dressings with skin tissue and their effect on the process of skin wound healing. In this context, the aim of this work was to perform a systematic review of the literature to examine the effects of 3D printed wound constructs on the process of skin wound healing in animal models. The articles were selected from three databases following Medical Subject Headings (MeSH) descriptors "3D printing," "skin," "wound," and "in vivo." After the selection, exclusion and inclusion criteria, nine articles were analyzed. This review confirms the significant benefits of using 3D printed wound constructs for skin repair and regeneration. All the used inks demonstrated the ability of mimicking the structure of skin tissue and promoting cell adhesion, proliferation, migration, and mobility. Furthermore, in vivo findings showed full wound closure in most of the studies, with well-organized dermal and epidermal layers.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Pele
/
Engenharia Tecidual
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article