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The discovery of 12ß-methyl-17-epi-18-nor-bile acids as potent and selective TGR5 agonists.
Luxenburger, Andreas; Harris, Lawrence D; Ure, Elizabeth M; Jiao, Wanting; Woolhouse, Anthony D; Cameron, Scott A; Weymouth-Wilson, Alex; Furneaux, Richard H; Pitman, Janet L; Hinkley, Simon F R.
Afiliação
  • Luxenburger A; Ferrier Research Institute, Victoria University of Wellington, 69 Gracefield Rd, Lower Hutt, 5040, New Zealand. Electronic address: Andreas.Luxenburger@vuw.ac.nz.
  • Harris LD; Ferrier Research Institute, Victoria University of Wellington, 69 Gracefield Rd, Lower Hutt, 5040, New Zealand.
  • Ure EM; Ferrier Research Institute, Victoria University of Wellington, 69 Gracefield Rd, Lower Hutt, 5040, New Zealand.
  • Jiao W; Ferrier Research Institute, Victoria University of Wellington, 69 Gracefield Rd, Lower Hutt, 5040, New Zealand.
  • Woolhouse AD; Ferrier Research Institute, Victoria University of Wellington, 69 Gracefield Rd, Lower Hutt, 5040, New Zealand.
  • Cameron SA; Ferrier Research Institute, Victoria University of Wellington, 69 Gracefield Rd, Lower Hutt, 5040, New Zealand.
  • Weymouth-Wilson A; ICE Pharma, 68 Weld Street, RD2, Palmerston North, 4472, New Zealand.
  • Furneaux RH; Ferrier Research Institute, Victoria University of Wellington, 69 Gracefield Rd, Lower Hutt, 5040, New Zealand.
  • Pitman JL; School of Biological Sciences, Victoria University of Wellington, Kelburn Parade, Wellington, 6012, New Zealand.
  • Hinkley SFR; Ferrier Research Institute, Victoria University of Wellington, 69 Gracefield Rd, Lower Hutt, 5040, New Zealand.
Eur J Med Chem ; 250: 115143, 2023 Mar 15.
Article em En | MEDLINE | ID: mdl-36841086
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Ácidos e Sais Biliares / Receptores Acoplados a Proteínas G Idioma: En Ano de publicação: 2023 Tipo de documento: Article
Texto completo
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XML
PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Ácidos e Sais Biliares / Receptores Acoplados a Proteínas G Idioma: En Ano de publicação: 2023 Tipo de documento: Article