NIR C-Myc Pu22 G-quadruplex probe as a photosensitizer for bioimaging and antitumor study.
Spectrochim Acta A Mol Biomol Spectrosc
; 294: 122533, 2023 Jun 05.
Article
em En
| MEDLINE
| ID: mdl-36842212
ABSTRACT
Despite the fact that C-Myc G-quadruplex in the oncogene promoter regions is one of the crucial targets of antitumor drugs, the selectivities and proliferation inhibitions of its probes towards tumor cells remain a big challenge. Until now, no effective C-Myc G-quadruplex probes have been reported as a photosensitizer to increase their antitumor activities. Here, the first NIR C-Myc G-quadruplex probe PDS-SQ has been designed, comprising a G-quadruplex binder PDS and a squaraine dye SQ as a photosensitizer. Conjugate PDS-SQ could selectively NIR image C-Myc Pu22 G-quadruplex in tumor cells, and show stronger antitumor activity in the irradiation by a chemo-photodynamic method than in the dark. The study provides a new way to develop the novel NIR C-Myc G-quadruplex probes with more potent antitumor activities.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Quadruplex G
/
Antineoplásicos
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article