A cross-sectional study of avian influenza A virus in Myanmar live bird markets: Detection of a newly introduced H9N2?
Influenza Other Respir Viruses
; 17(2): e13111, 2023 02.
Article
em En
| MEDLINE
| ID: mdl-36843223
ABSTRACT
BACKGROUND:
Zoonotic influenza surveillance in Myanmar is sparse, despite the risks of introduction of such viruses from neighboring countries that could impact the poultry industry and lead to spillover to humans.METHODS:
In July and August 2019, our multi-institutional partnership conducted a One Health-oriented, cross-sectional surveillance (weekly for 3 weeks) for influenza A and influenza D viruses at the three largest live bird markets in Yangon, Myanmar.RESULTS:
The 27 bioaerosols, 90 bird cage swabs, 90 bird oropharyngeals, and 90 human nasopharyngeal samples yielded molecular influenza A detections in 8 bioaerosols (30.0%), 16 bird cages (17.8%), 15 bird oropharyngeals (16.7%), and 1 human nasopharyngeal (1.1%) samples. No influenza D was detected. Seven of the influenza A virus detections were found to be subtype A/H9N2, and one human nasopharyngeal sample was found to be subtype A/H1pdm. Among all IAV-positive samples, three of the A/H9N2-positive samples yielded live viruses from egg culture and their whole genome sequences revealing they belonged to the G9/Y280 lineage of A/H9N2 viruses. Phylogenetic analyses showed that these A/H9N2 sequences clustered separately from A/H9N2 viruses that were previously detected in Myanmar, supporting the notion that A/H9N2 viruses similar to those seen in wider Southeast Asia may have been introduced to Myanmar on multiple occasions.CONCLUSIONS:
These findings call for increased surveillance efforts in Myanmar to monitor for the introduction of novel influenza viruses in poultry, as well as possible reassortment and zoonotic virus transmission.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Doenças das Aves Domésticas
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Influenza Humana
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Vírus da Influenza A Subtipo H9N2
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Influenza Aviária
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article