Inhibition of human APE1 and MTH1 DNA repair proteins by dextran-coated γ-Fe2O3 ultrasmall superparamagnetic iron oxide nanoparticles.
Nanomedicine (Lond)
; 17(26): 2011-2021, 2022 11.
Article
em En
| MEDLINE
| ID: mdl-36853189
Inhibitors of DNA repair proteins are increasingly being utilized as potential anticancer agents to supplement traditional chemotherapy and radiation-based approaches. The present study was focused on investigating the use of iron oxide nanoparticles to inhibit the expression of relevant human DNA repair proteins in a cellular model (MCL-5 cells). The authors utilized liquid chromatographytandem mass spectrometry with isotope dilution to measure the expression levels of two different DNA repair proteins (MTH1 and APE1) in cells after the cells were exposed to increasing levels of the iron oxide nanoparticles. The authors observed significant decreases in DNA repair protein levels that were associated with increasing doses of the iron oxide nanoparticles. The authors' findings warrant more comprehensive studies using other cellular models and suitable animal models.
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Base de dados:
MEDLINE
Assunto principal:
Dextranos
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Nanopartículas Magnéticas de Óxido de Ferro
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article