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Proxy gene-by-environment Mendelian randomization study of the association between cigarette smoking during pregnancy and offspring mental health.
Sallis, Hannah M; Wootton, Robyn E; Davey Smith, George; Munafò, Marcus R.
Afiliação
  • Sallis HM; Centre for Academic Mental Health, Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.
  • Wootton RE; MRC Integrative Epidemiology Unit (IEU) at the University of Bristol, Bristol, UK.
  • Davey Smith G; MRC Integrative Epidemiology Unit (IEU) at the University of Bristol, Bristol, UK.
  • Munafò MR; Nic Waals Institute, Lovisenberg Diaconal Hospital, Oslo, Norway.
Int J Epidemiol ; 52(5): 1350-1359, 2023 10 05.
Article em En | MEDLINE | ID: mdl-36860174
ABSTRACT

BACKGROUND:

Smoking prevalence is higher among individuals with schizophrenia or depression, and previous work has suggested this relationship is causal. However, this may be due to dynastic effects, for example reflecting maternal smoking during pregnancy rather than a direct effect of smoking. We used a proxy gene-by-environment Mendelian randomization approach to investigate whether there is a causal effect of maternal heaviness of smoking during pregnancy on offspring mental health.

METHODS:

Analyses were performed in the UK Biobank cohort. Individuals with data on smoking status, maternal smoking during pregnancy, a diagnosis of schizophrenia or depression, and genetic data were included. We used participants' genotype (rs16969968 in the CHRNA5 gene) as a proxy for their mothers' genotype. Analyses were stratified on participants' own smoking status in order to estimate the effect of maternal smoking heaviness during pregnancy independently of offspring smoking.

RESULTS:

The effect of maternal smoking on offspring schizophrenia was in opposing directions when stratifying on offspring smoking status. Among offspring of never smokers, each additional risk allele for maternal smoking heaviness appeared to have a protective effect [odds ratio (OR) = 0.77, 95% confidence interval (CI) 0.62 to 0.95, P = 0.015], whereas among ever smokers the effect of maternal smoking was in the reverse direction (OR = 1.23, 95% CI 1.05 to 1.45, P = 0.011, Pinteraction <0.001). There was no clear evidence of an association between maternal smoking heaviness and offspring depression.

CONCLUSIONS:

These findings do not provide clear evidence of an effect of maternal smoking during pregnancy on offspring schizophrenia or depression, which implies that any causal effect of smoking on schizophrenia or depression is direct.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Efeitos Tardios da Exposição Pré-Natal / Fumar Cigarros Idioma: En Ano de publicação: 2023 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Efeitos Tardios da Exposição Pré-Natal / Fumar Cigarros Idioma: En Ano de publicação: 2023 Tipo de documento: Article