The impact of SARS-CoV-2 infection on the outcome of acute ischemic stroke-A retrospective cohort study.
PLoS One
; 18(3): e0282045, 2023.
Article
em En
| MEDLINE
| ID: mdl-36862706
ABSTRACT
BACKGROUND:
Acute ischemic stroke (AIS) is a common complication of severe acute respiratory syndrome coronavirus 2 (SARSCoV2) infection (COVID-19), but the prognosis of these patients is poorly understood.PURPOSE:
To explore the impact of COVID-19 on neurological outcomes in AIS patients.METHODS:
A comparative retrospective cohort study was conducted in 32 consecutive AIS patients with and 51 without COVID-19 between the 1st of March 2020 and 1st of May 2021. The evaluation was based on a detailed chart review for demographic data, medical history, stroke severity, cranial and vessel imaging results, laboratory parameters, COVID-19 severity, hospitalization time, in-hospital mortality, and functional deficits at discharge (modified Rankin Scale, mRS).RESULTS:
COVID-19 AIS patients showed tendency to worse initial neurological deficit (NIHSS 9 (3-13) vs. 4 (2-10); p = 0.06), higher rate of large vessel occlusion (LVO; 13/32 vs. 14/51; p = 0.21), had prolonged hospitalization (19.4 ± 17.7 vs. 9.7 ± 7 days; p = 0.003), had lower chance of functional independence (mRS≤2) (12/32 vs. 32/51; p = 0.02) and showed higher in-hospital mortality (10/32 vs. 6/51; p = 0.02). In COVID-19 AIS patients, LVO was more common with COVID-19 pneumonia than without (55.6% vs. 23.1%; p = 0.139).CONCLUSION:
COVID-19-related AIS carries a worse prognosis. COVID-19 with pneumonia seems to be associated with a higher rate of LVO.
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Acidente Vascular Cerebral
/
AVC Isquêmico
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COVID-19
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article