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Data-driven subgroups of prediabetes and the associations with outcomes in Chinese adults.
Zheng, Ruizhi; Xu, Yu; Li, Mian; Gao, Zhengnan; Wang, Guixia; Hou, Xinguo; Chen, Li; Huo, Yanan; Qin, Guijun; Yan, Li; Wan, Qin; Zeng, Tianshu; Chen, Lulu; Shi, Lixin; Hu, Ruying; Tang, Xulei; Su, Qing; Yu, Xuefeng; Qin, Yingfen; Chen, Gang; Gu, Xuejiang; Shen, Feixia; Luo, Zuojie; Chen, Yuhong; Zhang, Yinfei; Liu, Chao; Wang, Youmin; Wu, Shengli; Yang, Tao; Li, Qiang; Mu, Yiming; Zhao, Jiajun; Hu, Chunyan; Jia, Xiaojing; Xu, Min; Wang, Tiange; Zhao, Zhiyun; Wang, Shuangyuan; Lin, Hong; Ning, Guang; Wang, Weiqing; Lu, Jieli; Bi, Yufang.
Afiliação
  • Zheng R; Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China; Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Dis
  • Xu Y; Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China; Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Dis
  • Li M; Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China; Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Dis
  • Gao Z; Dalian Municipal Central Hospital, Dalian, China.
  • Wang G; The First Hospital of Jilin University, Changchun, China.
  • Hou X; Qilu Hospital of Shandong University, Jinan, China.
  • Chen L; Qilu Hospital of Shandong University, Jinan, China.
  • Huo Y; Jiangxi Provincial People's Hospital Affiliated to Nanchang University, Nanchang, China.
  • Qin G; The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
  • Yan L; Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.
  • Wan Q; The Affiliated Hospital of Southwest Medical University, Luzhou, China.
  • Zeng T; Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  • Chen L; Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  • Shi L; Affiliated Hospital of Guiyang Medical College, Guiyang, China.
  • Hu R; Zhejiang Provincial Center for Disease Control and Prevention, China.
  • Tang X; The First Hospital of Lanzhou University, Lanzhou, China.
  • Su Q; Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China.
  • Yu X; Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  • Qin Y; The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
  • Chen G; Fujian Provincial Hospital, Fujian Medical University, Fuzhou, China.
  • Gu X; The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
  • Shen F; The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
  • Luo Z; The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
  • Chen Y; Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China; Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Dis
  • Zhang Y; Central Hospital of Shanghai Jiading District, Shanghai, China.
  • Liu C; Jiangsu Province Hospital on Integration of Chinese and Western Medicine, Nanjing, China.
  • Wang Y; The First Affiliated Hospital of Anhui Medical University, Hefei, China.
  • Wu S; Karamay Municipal People's Hospital, Xinjiang, China.
  • Yang T; The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
  • Li Q; The Second Affiliated Hospital of Harbin Medical University, Harbin, China.
  • Mu Y; Chinese People's Liberation Army General Hospital, Beijing, China.
  • Zhao J; Shandong Provincial Hospital Affiliated to Shandong University, Jinan, China.
  • Hu C; Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China; Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Dis
  • Jia X; Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China; Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Dis
  • Xu M; Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China; Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Dis
  • Wang T; Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China; Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Dis
  • Zhao Z; Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China; Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Dis
  • Wang S; Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China; Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Dis
  • Lin H; Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China; Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Dis
  • Ning G; Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China; Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Dis
  • Wang W; Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China; Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Dis
  • Lu J; Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China; Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Dis
  • Bi Y; Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China; Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Dis
Cell Rep Med ; 4(3): 100958, 2023 03 21.
Article em En | MEDLINE | ID: mdl-36863337
ABSTRACT
Prediabetes and its pathophysiology remain important issues. We aimed to examine the cluster characteristics of prediabetes and explore their associations with developing diabetes and its complications based on 12 variables representing body fat, glycemic measures, pancreatic ß cell function, insulin resistance, blood lipids, and liver enzymes. A total of 55,777 individuals with prediabetes from the China Cardiometabolic Disease and Cancer Cohort (4C) were classified at baseline into six clusters. During a median of 3.1 years of follow-up, significant differences in the risks of diabetes and its complications between clusters were observed. The odds ratios of diabetes stepwisely increase from cluster 1 to cluster 6. Clusters 1, 4, and 6 have increased chronic kidney diseases risks, while the prediabetes in cluster 4, characterized by obesity and insulin resistance, confers higher risks of cardiovascular diseases compared with others. This subcategorization has potential value in developing more precise strategies for targeted prediabetes prevention and treatment.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Estado Pré-Diabético / Resistência à Insulina / Diabetes Mellitus Idioma: En Ano de publicação: 2023 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Estado Pré-Diabético / Resistência à Insulina / Diabetes Mellitus Idioma: En Ano de publicação: 2023 Tipo de documento: Article