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Genetic hemochromatosis is not a risk factor for Restless Legs Syndrome.
Martin, Morgane; De-Lédinghen, Victor; Ghorayeb, Imad.
Afiliação
  • Martin M; Université de Bordeaux, Institut de Neurosciences Cognitives et Intégratives d'Aquitaine, UMR 5287, F-33076, Bordeaux, France; CNRS, Institut de Neurosciences Cognitives et Intégratives d'Aquitaine, UMR 5287, F-33076, Bordeaux, France.
  • De-Lédinghen V; Service d'hépato-gastroentérologie, Hôpital Haut-Lévêque, CHU Bordeaux, Pessac, et INSERM U1312, Université de Bordeaux, Bordeaux, France.
  • Ghorayeb I; Université de Bordeaux, Institut de Neurosciences Cognitives et Intégratives d'Aquitaine, UMR 5287, F-33076, Bordeaux, France; CNRS, Institut de Neurosciences Cognitives et Intégratives d'Aquitaine, UMR 5287, F-33076, Bordeaux, France; Département de Neurophysiologie Clinique, Pôle Neurosciences Cliniques, CHU de Bordeaux, F-33076, Bordeaux, France. Electronic address: imad.ghorayeb@u-bordeaux.fr.
Sleep Med ; 104: 18-21, 2023 04.
Article em En | MEDLINE | ID: mdl-36870323
ABSTRACT

BACKGROUND:

Iron dysmetabolism has long been identified as a primary key factor involved in Restless Legs Syndrome (RLS) pathophysiology and may account for the high prevalence of RLS observed in chronic liver diseases (CLD). Prevalence of RLS was also reported to be high in genetic hemochromatosis (GH) but whether this is due to the unique iron metabolism disorder and to treatment procedure in GH remains unknown. If this assumption is true, then one would hypothesize that RLS prevalence is higher in GH than in another CLD such as chronic hepatitis B (CHB). MATERIALS AND

METHODS:

We conducted a prospective questionnaire-based survey to assess the prevalence of RLS symptoms in consecutive patients with either GH or CHB. Patients who were screened positive for RLS based on the criteria of the International RLS Study Group were further interviewed by telephone and if needed by face to face assessment to confirm RLS diagnosis.

RESULTS:

Symptoms of confirmed RLS were confirmed in 8.9% of the 101 participants with CHB and in 10% of the 105 patients with GH. Low ferritin levels were not associated with the presence of RLS in both groups nor were the severity of the liver disease.

CONCLUSION:

GH is not a risk factor for RLS occurrence as any other cause of CLD, as RLS prevalence in both GH and CHB is within the range of RLS prevalence in the general Caucasian population.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Síndrome das Pernas Inquietas / Hemocromatose Idioma: En Ano de publicação: 2023 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Síndrome das Pernas Inquietas / Hemocromatose Idioma: En Ano de publicação: 2023 Tipo de documento: Article