Prenatally VPA exposure is likely to cause autistic-like behavior in the rats offspring via TREM2 down-regulation to affect the microglial activation and synapse alterations.

Luo, Lijuan; Chen, Jie; Wu, Qionghui; Yuan, Binlin; Hu, Chaoqun; Yang, Ting; Wei, Hua; Li, Tingyu

Luo, Lijuan; Chen, Jie; Wu, Qionghui; Yuan, Binlin; Hu, Chaoqun; Yang, Ting; Wei, Hua; Li, Tingyu.

Afiliação

Luo L; Children's Nutrition Research Center, Children's Hospital of Chongqing Medical University, Chongqing Key Laboratory of Child Nutrition and Health, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing, Chi
Chen J; Children's Nutrition Research Center, Children's Hospital of Chongqing Medical University, Chongqing Key Laboratory of Child Nutrition and Health, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing, Chi
Wu Q; Children's Nutrition Research Center, Children's Hospital of Chongqing Medical University, Chongqing Key Laboratory of Child Nutrition and Health, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing, Chi
Yuan B; Children's Nutrition Research Center, Children's Hospital of Chongqing Medical University, Chongqing Key Laboratory of Child Nutrition and Health, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing, Chi
Hu C; Children's Nutrition Research Center, Children's Hospital of Chongqing Medical University, Chongqing Key Laboratory of Child Nutrition and Health, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing, Chi
Yang T; Children's Nutrition Research Center, Children's Hospital of Chongqing Medical University, Chongqing Key Laboratory of Child Nutrition and Health, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing, Chi
Wei H; Children's Nutrition Research Center, Children's Hospital of Chongqing Medical University, Chongqing Key Laboratory of Child Nutrition and Health, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing, Chi
Li T; Children's Nutrition Research Center, Children's Hospital of Chongqing Medical University, Chongqing Key Laboratory of Child Nutrition and Health, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing, Chi

Environ Toxicol Pharmacol ; 99: 104090, 2023 Apr.

Article em En | MEDLINE | ID: mdl-36870407

Assuntos

Transtorno do Espectro Autista; Transtorno Autístico; Efeitos Tardios da Exposição Pré-Natal; Gravidez; Feminino; Ratos; Animais; Humanos; Ácido Valproico/toxicidade; Transtorno Autístico/induzido quimicamente; Microglia; Regulação para Baixo; Sinapses; Efeitos Tardios da Exposição Pré-Natal/induzido quimicamente; Modelos Animais de Doenças; Comportamento Animal; Glicoproteínas de Membrana/genética; Glicoproteínas de Membrana/efeitos adversos; Receptores Imunológicos/genética

Palavras-chave

Autism spectrum disorders; Microglial activation; Microglial polarization; Synaptic pruning; Triggering receptor expressed on myeloid cells 2; Valproic acid

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Efeitos Tardios da Exposição Pré-Natal / Transtorno Autístico / Transtorno do Espectro Autista Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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