Brain functional specialization in obsessive-compulsive disorder associated with neurotransmitter profiles.
J Affect Disord
; 329: 477-482, 2023 05 15.
Article
em En
| MEDLINE
| ID: mdl-36871908
ABSTRACT
BACKGROUND:
Cerebral specialization is an important functional architecture of the human brain. Abnormal cerebral specialization may be the underlying pathogenesis of obsessive-compulsive disorder (OCD). Resting-state functional magnetic resonance imaging (rs-fMRI) was used to show that the specialization pattern of OCD was of great significance for early warning and precise intervention of the disease.METHOD:
The autonomy index (AI) based on the rs-fMRI was calculated to compare brain specializations between 80 OCD patients and 81 matched healthy controls (HCs). In addition, we also correlated the AI alteration patterns with neurotransmitter receptor/transporter densities.RESULTS:
OCD patients showed increased AI in the right insula and right superior temporal gyrus when compared with HCs. In addition, AI differences were associated with serotonin receptors (5-HT1AR and 5HT4R), dopamine D2 receptors, norepinephrine transporters, and metabotropic glutamate receptor densities.LIMITATIONS:
Drug effect; cross-sectional study design; the selection of positron emission tomography template.CONCLUSIONS:
This study showed abnormal specialization patterns in OCD patients, which may lead to the elucidation of the underlying pathological mechanism of the disease.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Imageamento por Ressonância Magnética
/
Transtorno Obsessivo-Compulsivo
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article