Indirect bilirubin impairs invasion of osteosarcoma cells <i>via</i> inhibiting the PI3K/AKT/MMP-2 signaling pathway by suppressing intracellular ROS.

Yuan, Xuhui; Ma, Cong; Li, Jiayu; Li, Junhong; Yu, Ronghui; Cai, Feng; Qu, Gaoyang; Yu, Bo; Liu, Lang; Zeng, Duo; Jiao, QuanHui; Liao, Qi; Lv, Xiaobin

Indirect bilirubin impairs invasion of osteosarcoma cells via inhibiting the PI3K/AKT/MMP-2 signaling pathway by suppressing intracellular ROS.

Yuan, Xuhui; Ma, Cong; Li, Jiayu; Li, Junhong; Yu, Ronghui; Cai, Feng; Qu, Gaoyang; Yu, Bo; Liu, Lang; Zeng, Duo; Jiao, QuanHui; Liao, Qi; Lv, Xiaobin.

Afiliação

Yuan X; Jiangxi Key Laboratory of Cancer Metastasis and Precision Treatment, Central Laboratory, The First Hospital of Nanchang, The Third Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330008, China.
Ma C; Department of Orthopedics, The First Hospital of Nanchang, The Third Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330008, China.
Li J; Department of Orthopedics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China.
Li J; Jiangxi Key Laboratory of Cancer Metastasis and Precision Treatment, Central Laboratory, The First Hospital of Nanchang, The Third Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330008, China.
Yu R; Department of Orthopedics, The First Hospital of Nanchang, The Third Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330008, China.
Cai F; Department of Orthopedics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China.
Qu G; Department of Orthopedics, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, China.
Yu B; Jiangxi Key Laboratory of Cancer Metastasis and Precision Treatment, Central Laboratory, The First Hospital of Nanchang, The Third Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330008, China.
Liu L; Department of Orthopedics, The First Hospital of Nanchang, The Third Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330008, China.
Zeng D; Department of Orthopedics, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, China.
Jiao Q; Jiangxi Key Laboratory of Cancer Metastasis and Precision Treatment, Central Laboratory, The First Hospital of Nanchang, The Third Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330008, China.
Liao Q; Department of Orthopedics, The First Hospital of Nanchang, The Third Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330008, China.
Lv X; Department of Orthopedics, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, China.

J Bone Oncol ; 39: 100472, 2023 Apr.

Article em En | MEDLINE | ID: mdl-36876225

Palavras-chave

AUC, area under curve; BRNP, PEGylated bilirubin nanoparticles; CCK-8, cell counting kit-8; CI, confidence interval; DBIL, direct bilirubin; DMSO, dimethyl sulfoxide; ECM, extracellular matrix; H2O2, hydrogen peroxide; HIF-1α, hypoxia inducible factor-1α; HR, hazard ratio; IBIL; IBIL, indirect bilirubin; Invasion; MDA, malondialdehyde; MMP, matrix metalloproteinase; OS, overall survival; Osteosarcoma; PFS, progression-free survival; PI3K/AKT/MMP-2; PVDF, polyvinylidene fluoride; Prognosis; ROC, receiver operative characteristic; ROS, reactive oxygen species; SD, standard deviation; SOD, superoxide dismutase; TBIL, total bilirubin; TIMP, tissue inhibitor of matrix metalloproteinase; VEGF, vascular endothelial growth factor; qRT-PCR, real-time quantitative PCR

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