Could immune-related hepatitis rapidly progress to immune-related cirrhosis?
Eur Rev Med Pharmacol Sci
; 27(4): 1436-1442, 2023 02.
Article
em En
| MEDLINE
| ID: mdl-36876683
ABSTRACT
BACKGROUND:
Immune-related hepatitis is one of the prevalent adverse events associated with immunotherapy, especially immune checkpoint inhibitors (ICIs). For patients without a history of liver disease, autoimmune disease, or alcohol consumption, it is not clear whether immune-related hepatitis could rapid progress to immune-related cirrhosis. CASE REPORT We report the case of a 54-year-old female with stage IIIB primary pulmonary lymphoepithelioma-like carcinoma (PLELC) diagnosed with immune-related hepatitis. After 15 months, a liver biopsy demonstrated the rapid progression of liver cirrhosis although systematic corticosteroid administration.CONCLUSIONS:
Long-term immune activation caused by ICIs may exacerbate the process of cirrhosis. Great attention should be paid to the rapid progression to liver cirrhosis of immune-related hepatitis in the clinic.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Doenças Autoimunes
/
Hepatite
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article