Association Between the Neutrophil-to-Lymphocyte Ratio and Infection and Survival in Diffuse Large B Cell Lymphoma.
In Vivo
; 37(2): 948-954, 2023.
Article
em En
| MEDLINE
| ID: mdl-36881069
ABSTRACT
BACKGROUND/AIM:
Infection is a common cause of morbidity and mortality in patients treated for diffuse large B-cell lymphoma (DLBCL). However, there is limited information on the impact and risk factors for infection among patients receiving rituximab, cyclophosphamide, vincristine, doxorubicin, and prednisolone (R-CHOP). PATIENTS ANDMETHODS:
A retrospective study evaluating patients with DLBCL receiving R-CHOP and R-COP between 2004 and 2021 was conducted at a medical center. Hospital patients' records for the five-item modified frailty index (mFI-5), sarcopenia, blood-based inflammatory markers, and clinical outcomes were statistically analyzed.RESULTS:
Patients with frailty, sarcopenia, and high neutrophil-to-lymphocyte ratio (NLR) were associated with a higher risk of infections. The revised International Prognostic Index poor-risk group, high NLR, infections, and treatment modality were risk factors for shorter progression-free and overall survival.CONCLUSION:
Pre-treatment high NLR was a predictor of infection and survival outcome in DLBCL patients.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Linfoma Difuso de Grandes Células B
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Sarcopenia
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Fragilidade
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article