Construction of C(CO)-C(CO) Bond via NHC-Catalyzed Radical Cross-Coupling Reaction.
Org Lett
; 25(11): 1829-1833, 2023 Mar 24.
Article
em En
| MEDLINE
| ID: mdl-36897255
ABSTRACT
A C(sp2)-C(sp2) bond can be constructed via a photoredox/N-heterocyclic carbene (NHC)-cocatalyzed radical cross-coupling reaction, which provides a complementary strategy to classic electron pair processes. The present protocol represents the first example of an NHC-catalyzed two-component radical cross-coupling reaction involving C(sp2)-centered radical species. The decarboxylative acylation of oxamic acid with acyl fluoride was conducted under mild conditions and allowed the preparation of a variety of useful α-keto amides, including sterically congested ones.
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MEDLINE
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En
Ano de publicação:
2023
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Article