Hormone replacement treatment regimen is associated with a higher risk of hypertensive disorders of pregnancy in women undergoing frozen-thawed embryo transfer.
Front Endocrinol (Lausanne)
; 14: 1133978, 2023.
Article
em En
| MEDLINE
| ID: mdl-36909329
ABSTRACT
Introduction:
In frozen-thawed embryo transfer (FET) cycles, hormone replacement treatment (HRT) was associated with a higher risk of hypertensive disorders of pregnancy (HDP) compared with natural cycles (NC). Multiple pregnancy was a risk factor for HDP and several studies did not conduct subgroup analysis of singleton pregnancy and multiple pregnancy.Objective:
To investigate whether HRT regimen could be a risk factor for HDP in women undergoing FET cycles in singleton and twin pregnancies.Methods:
A retrospective cohort study at a tertiary hospital, including a total of 9120 women who underwent FET and achieved ongoing pregnancy; 7590 patients underwent HRT-FET and 1530 NC-FET. The main outcome was HDP. HDP were analyzed for singleton and twin pregnancies, respectively.Results:
In the singleton pregnancy, the risk of HDP in the HRT-FET group was significantly higher than that in the NC-FET group (6.21% vs. 4.09%; P=0.003). After adjusting for female age oocyte pick up, female age at FET and body mass index (BMI), HRT was found as a risk factor for HDP (adjusted odds ration [aOR] 1.43; 95% confidence interval [CI] 1.07 to 1.91; P=0.017). In the multiple pregnancy, the risk of HDP in the HRT-FET and NC-FET groups was similar.Conclusion:
HRT was associated with a higher risk of HDP in women who underwent FET and achieved singleton pregnancy.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Hipertensão Induzida pela Gravidez
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article