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Effects of radiofrequency balloon angioplasty on the abdominal aorta in atherosclerotic rabbits.
Xia, Xiaodong; Wang, Lijun; Sun, Pengyu; Liu, Yu; Liu, Hongze; Li, Jiao; Chen, Qiang; Shangguan, Wenfeng; Wang, Weiding; Miao, Shuai; Gu, Tianshu; Liu, Enzhao; Liang, Xue; Li, Guangping.
Afiliação
  • Xia X; Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular Disease, Department of Cardiology, Tianjin Institute of Cardiology, The Second Hospital of Tianjin Medical University Tianjin 300211, China.
  • Wang L; Department of Emergency Medicine, Tianjin Medical University General Hospital Tianjin 300052, China.
  • Sun P; Department of Emergency Medicine, Tianjin Medical University General Hospital Tianjin 300052, China.
  • Liu Y; Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular Disease, Department of Cardiology, Tianjin Institute of Cardiology, The Second Hospital of Tianjin Medical University Tianjin 300211, China.
  • Liu H; Taikang Ningbo Hospital Ningbo 315100, Zhejiang, China.
  • Li J; Department of Cardiology, Tianjin Union Medical Center, Nankai University Affiliated Hospital Tianjin 300121, China.
  • Chen Q; Department of Cardiology, Tianjin Union Medical Center, Nankai University Affiliated Hospital Tianjin 300121, China.
  • Shangguan W; Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular Disease, Department of Cardiology, Tianjin Institute of Cardiology, The Second Hospital of Tianjin Medical University Tianjin 300211, China.
  • Wang W; Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular Disease, Department of Cardiology, Tianjin Institute of Cardiology, The Second Hospital of Tianjin Medical University Tianjin 300211, China.
  • Miao S; Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular Disease, Department of Cardiology, Tianjin Institute of Cardiology, The Second Hospital of Tianjin Medical University Tianjin 300211, China.
  • Gu T; Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular Disease, Department of Cardiology, Tianjin Institute of Cardiology, The Second Hospital of Tianjin Medical University Tianjin 300211, China.
  • Liu E; Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular Disease, Department of Cardiology, Tianjin Institute of Cardiology, The Second Hospital of Tianjin Medical University Tianjin 300211, China.
  • Liang X; Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular Disease, Department of Cardiology, Tianjin Institute of Cardiology, The Second Hospital of Tianjin Medical University Tianjin 300211, China.
  • Li G; Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular Disease, Department of Cardiology, Tianjin Institute of Cardiology, The Second Hospital of Tianjin Medical University Tianjin 300211, China.
Am J Transl Res ; 15(2): 1041-1051, 2023.
Article em En | MEDLINE | ID: mdl-36915727
OBJECTIVES: A novel temperature-controlled intravascular radiofrequency balloon angioplasty (RFBA) technique was designed and developed for atherosclerosis (AS) management. METHODS: After establishing an AS model based on a balloon denudation injury of the abdominal aorta and a high cholesterol diet in rabbits, 46 animals were randomly assigned to the RFBA group (n = 28) or the plain balloon angioplasty (PBA) group (n = 28). The groups were further subdivided based on post-treatment euthanasia times (1 hour, 7 days, 14 days, and 28 days). Histopathological changes were observed by hematoxylin and eosin and Masson's staining. Immunohistochemistry, western blotting, and real-time quantitative polymerase chain reaction were used to detect changes in pro-inflammatory, anti-inflammatory, and apoptotic factors; TGF-ß/Smad-2 pathway protein Immune levels; and mRNA levels in tissues, respectively. RESULTS: The vascular lumen area in the RFBA group was larger than that in the PBA group at the same time points, although the change in the vascular lumen area was not different between groups. The expression of Bax, TGF-ß, Smad-2, and Caspase-3 in the RFBA group was significantly higher than that in the PBA group. The expression levels of Bcl-2 in the RFBA group were significantly lower than those in the PBA group. CONCLUSIONS: At 28 days, RFBA dilated the atherosclerotic blood vessels and thickened the fibrous cap of atherosclerotic plaques to promote plaque stability. RFBA was also found to activate apoptotic factors and the TGF-/Smad-2 inflammatory pathway.
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2023 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2023 Tipo de documento: Article