Your browser doesn't support javascript.
loading
Successful Treatment of Metastatic Gallbladder Carcinoma with a High Tumor Mutational Burden Using Pembrolizumab.
Uehara, Sanae; Naganuma, Atsushi; Furuichi, Nozomi; Furusawa, Ai; Kaburagi, Takuya; Naruse, Hiroaki; Tomaru, Shota; Sano, Nozomi; Suzuki, Yuhei; Masuda, Tomoyuki; Hoshino, Takashi; Yasuoka, Hidetoshi; Tanaka, Yuko; Saito, Shuichi; Hatanaka, Takeshi; Kakizaki, Satoru.
Afiliação
  • Uehara S; Department of Gastroenterology, National Hospital Organization Takasaki General Medical Center, Japan.
  • Naganuma A; Department of Gastroenterology, National Hospital Organization Takasaki General Medical Center, Japan.
  • Furuichi N; Department of Gastroenterology, National Hospital Organization Takasaki General Medical Center, Japan.
  • Furusawa A; Department of Gastroenterology, National Hospital Organization Takasaki General Medical Center, Japan.
  • Kaburagi T; Department of Gastroenterology, National Hospital Organization Takasaki General Medical Center, Japan.
  • Naruse H; Department of Gastroenterology, National Hospital Organization Takasaki General Medical Center, Japan.
  • Tomaru S; Department of Gastroenterology, National Hospital Organization Takasaki General Medical Center, Japan.
  • Sano N; Department of Gastroenterology, National Hospital Organization Takasaki General Medical Center, Japan.
  • Suzuki Y; Department of Gastroenterology, National Hospital Organization Takasaki General Medical Center, Japan.
  • Masuda T; Department of Gastroenterology, National Hospital Organization Takasaki General Medical Center, Japan.
  • Hoshino T; Department of Gastroenterology, National Hospital Organization Takasaki General Medical Center, Japan.
  • Yasuoka H; Department of Gastroenterology, National Hospital Organization Takasaki General Medical Center, Japan.
  • Tanaka Y; Department of Pathology, National Hospital Organization Takasaki General Medical Center, Japan.
  • Saito S; Department of Gastroenterology, Tomioka General Hospital, Japan.
  • Hatanaka T; Department of Gastroenterology, Gunma Saiseikai Maebashi Hospital, Japan.
  • Kakizaki S; Department of Gastroenterology, National Hospital Organization Takasaki General Medical Center, Japan.
Intern Med ; 62(21): 3151-3156, 2023 Nov 01.
Article em En | MEDLINE | ID: mdl-36927965
ABSTRACT
A woman in her 70s presented with gallbladder carcinoma with liver metastases and peritoneal dissemination. After standard chemotherapy failed, a liver biopsy was performed. A FoundationOne CDx analysis showed that the tumor mutational burden (TMB) was high (34 mutations/megabase). Treatment with pembrolizumab, which is an immune checkpoint inhibitor (ICI), resulted in a partial response, and there were no significant immune-related adverse events. According to recently published reports, the frequency of TMB-high biliary tract cancer (BTC) is 3.4-4%, which makes it extremely rare. In conclusion, ICIs may be effective in patients with TMB-high BTC.
Assuntos
Palavras-chave
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Carcinoma / Neoplasias da Vesícula Biliar / Neoplasias Pulmonares Idioma: En Ano de publicação: 2023 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Carcinoma / Neoplasias da Vesícula Biliar / Neoplasias Pulmonares Idioma: En Ano de publicação: 2023 Tipo de documento: Article