Endothelial-derived extracellular vesicles from obese/hypertensive adults increase factors associated with hypertrophy and fibrosis in cardiomyocytes.

Fandl, Hannah K; Garcia, Vinicius P; Treuth, John W; Brewster, Lillian M; Greiner, Jared J; Davy, Kevin P; Stauffer, Brian L; Desouza, Christopher A

Fandl, Hannah K; Garcia, Vinicius P; Treuth, John W; Brewster, Lillian M; Greiner, Jared J; Davy, Kevin P; Stauffer, Brian L; Desouza, Christopher A.

Afiliação

Fandl HK; Integrative Vascular Biology Laboratory, Department of Integrative Physiology, University of Colorado, Boulder, Colorado, United States.
Garcia VP; Integrative Vascular Biology Laboratory, Department of Integrative Physiology, University of Colorado, Boulder, Colorado, United States.
Treuth JW; Integrative Vascular Biology Laboratory, Department of Integrative Physiology, University of Colorado, Boulder, Colorado, United States.
Brewster LM; Integrative Vascular Biology Laboratory, Department of Integrative Physiology, University of Colorado, Boulder, Colorado, United States.
Greiner JJ; Integrative Vascular Biology Laboratory, Department of Integrative Physiology, University of Colorado, Boulder, Colorado, United States.
Davy KP; Human Integrative Physiology Laboratory, Department of Human Nutrition, Foods, and Exercise, Virginia Tech University, Blacksburg, Virginia, United States.
Stauffer BL; Division of Cardiology, Denver Health Medical Center, Denver, Colorado, United States.
Desouza CA; Division of Cardiology, Anschutz Medical Center, University of Colorado, Denver, Colorado, United States.

Am J Physiol Heart Circ Physiol ; 324(5): H675-H685, 2023 05 01.

Article em En | MEDLINE | ID: mdl-36930654

Assuntos

Micropartículas Derivadas de Células; Insuficiência Cardíaca; Hipertensão; Masculino; Feminino; Humanos; Adulto; Pessoa de Meia-Idade; Miócitos Cardíacos/metabolismo; Óxido Nítrico Sintase Tipo III/metabolismo; Troponina T/metabolismo; Óxido Nítrico/metabolismo; Actinina/metabolismo; Actinina/farmacologia; NF-kappa B/metabolismo; Hipertensão/metabolismo; Hipertrofia/metabolismo; Hipertrofia/patologia; Micropartículas Derivadas de Células/metabolismo; Obesidade/metabolismo; Insuficiência Cardíaca/metabolismo; Fator de Crescimento Transformador beta/metabolismo; Fibrose

Palavras-chave

cardiomyocytes; endothelial microvesicles; fibrosis; hypertrophy; nitric oxide

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Micropartículas Derivadas de Células / Insuficiência Cardíaca / Hipertensão Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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