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The long-lasting shadow of litter size in rodents: litter size is an underreported variable that strongly determines adult physiology.
Parra-Vargas, Marcela; Bouret, Sebastien G; Bruning, Jens C; de Moura, Egberto G; Garland, Theodore; Lisboa, Patricia C; Ozanne, Susan E; Patti, Mary-Elizabeth; Plagemann, Andreas; Speakman, John R; Tena-Sempere, Manuel; Vergely, Catherine; Zeltser, Lori M; Jiménez-Chillarón, Josep C.
Afiliação
  • Parra-Vargas M; Institut de Recerca Sant Joan de Déu, SJD-Barcelona Children's Hospital, Endocrine Division, Esplugues, Barcelona, Spain.
  • Bouret SG; Univ. Lille, Inserm, CHU Lille, Laboratory of Development and Plasticity of the Neuroendocrine Brain, Lille Neuroscience & Cognition, Inserm UMR-S1172, F-59000, Lille, France.
  • Bruning JC; Max Planck Institute for Metabolism Research, Policlinic for Endocrinology, Diabetes and Preventive Medicine, University Hospital Cologne, Cologne, Germany.
  • de Moura EG; Laboratory of Endocrine Physiology, Department of Physiological Sciences, Roberto Alcantara Gomes Biology Institute, State University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
  • Garland T; Department of Evolution, Ecology, and Organismal Biology, University of California, Riverside, Riverside, CA, USA.
  • Lisboa PC; Laboratory of Endocrine Physiology, Department of Physiological Sciences, Roberto Alcantara Gomes Biology Institute, State University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
  • Ozanne SE; University of Cambridge Metabolic Research Laboratories and MRC Metabolic Diseases Unit, Welcome-MRC Institute of Metabolic Science, University of Cambridge, UK.
  • Patti ME; Joslin Diabetes Center, Section of Integrative Physiology and Metabolism, Harvard Medical School, Boston, MA, USA.
  • Plagemann A; Division of 'Experimental Obstetrics,' Clinic of Obstetrics, Charité - Universitätsmedizin Berlin. Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.
  • Speakman JR; Shenzhen Key Laboratory of Metabolic Health, Center for Energy Metabolism and Reproduction, Shenzhen Institutes of Advanced Technology, Shenzhen, China.
  • Tena-Sempere M; Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), Department of Cell Biology, Physiology and Immunology, University of Córdoba, CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, Cordoba, Spain.
  • Vergely C; Pathophysiology and Epidemiology of Cerebro-Cardiovascular diseases (PEC2) research team, Faculty of Health Sciences, University of Bourgogne, Dijon, France.
  • Zeltser LM; Naomi Berrie Diabetes Center, Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, USA.
  • Jiménez-Chillarón JC; Institut de Recerca Sant Joan de Déu, SJD-Barcelona Children's Hospital, Endocrine Division, Esplugues, Barcelona, Spain; Department of Physiological Sciences, School of Medicine, University of Barcelona, L'Hospitalet, Barcelona, Spain. Electronic address: josep.jimenez@ub.edu.
Mol Metab ; 71: 101707, 2023 05.
Article em En | MEDLINE | ID: mdl-36933618
ABSTRACT
BACKGROUND/

PURPOSE:

Litter size is a biological variable that strongly influences adult physiology in rodents. Despite evidence from previous decades and recent studies highlighting its major impact on metabolism, information about litter size is currently underreported in the scientific literature. Here, we urge that this important biological variable should be explicitly stated in research articles. RESULTS/

CONCLUSION:

Below, we briefly describe the scientific evidence supporting the impact of litter size on adult physiology and outline a series of recommendations and guidelines to be implemented by investigators, funding agencies, editors in scientific journals, and animal suppliers to fill this important gap.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Roedores Idioma: En Ano de publicação: 2023 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Roedores Idioma: En Ano de publicação: 2023 Tipo de documento: Article