Expanding the 'aplysinospin cascade' through DNA-templated [2+2] photocycloaddition.
Chem Commun (Camb)
; 59(28): 4221-4224, 2023 Apr 04.
Article
em En
| MEDLINE
| ID: mdl-36939749
ABSTRACT
Inspired by the unique ability of nucleic acids to template chemical transformations that are otherwise impossible in solution, we embarked on the generalisation of our DNA-templated [2+2] photo-induced homo- and heterodimerization of aplysinopsins. Our process ensures a straightforward access to cyclobutane containing natural products and analogues thereof. Most importantly, this conceptual biomimetic achievement presents interesting arguments to build a biosynthetic scenario.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
DNA
/
Ácidos Nucleicos
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article