Child maltreatment and telomere length in middle and older age: retrospective cohort study of 141 748 UK Biobank participants.
Br J Psychiatry
; 223(2): 377-381, 2023 08.
Article
em En
| MEDLINE
| ID: mdl-36946056
ABSTRACT
BACKGROUND:
There is evidence that child maltreatment is associated with shorter telomere length in early life.AIMS:
This study aims to examine if child maltreatment is associated with telomere length in middle- and older-age adults.METHOD:
This was a retrospective cohort study of 141 748 UK Biobank participants aged 37-73 years at recruitment. Leukocyte telomere length was measured with quantitative polymerase chain reaction, and log-transformed and scaled to have unit standard deviation. Child maltreatment was recalled by participants. Linear regression was used to analyse the association.RESULTS:
After adjusting for sociodemographic characteristics, participants with three or more types of maltreatment presented with the shortest telomere lengths (ß = -0.05, 95% CI -0.07 to -0.03; P < 0.0001), followed by those with two types of maltreatment (ß = -0.02, 95% CI -0.04 to 0.00; P = 0.02), referent to those who had none. When adjusted for depression and post-traumatic stress disorder, the telomere lengths of participants with three or more types of maltreatment were still shorter (ß = -0.04, 95% CI -0.07 to -0.02; P = 0.0008). The telomere lengths of those with one type of maltreatment were not significantly different from those who had none. When mutually adjusted, physical abuse (ß = -0.05, 95% CI -0.07 to -0.03; P < 0.0001) and sexual abuse (ß = -0.02, 95% CI -0.04 to 0.00; P = 0.02) were independently associated with shorter telomere length.CONCLUSIONS:
Our findings showed that child maltreatment is associated with shorter telomere length in middle- and older-aged adults, independent of sociodemographic and mental health factors.Palavras-chave
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MEDLINE
Assunto principal:
Telômero
/
Sobreviventes Adultos de Maus-Tratos Infantis
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article