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Sex differences, asymmetry, and age-related white matter development in infants and 5-year-olds as assessed with tract-based spatial statistics.
Kumpulainen, Venla; Merisaari, Harri; Silver, Eero; Copeland, Anni; Pulli, Elmo P; Lewis, John D; Saukko, Ekaterina; Shulist, Satu J; Saunavaara, Jani; Parkkola, Riitta; Lähdesmäki, Tuire; Karlsson, Linnea; Karlsson, Hasse; Tuulari, Jetro J.
Afiliação
  • Kumpulainen V; FinnBrain Birth Cohort Study, Turku Brain and Mind Center, Department of Clinical Medicine, University of Turku, Turku, Finland.
  • Merisaari H; FinnBrain Birth Cohort Study, Turku Brain and Mind Center, Department of Clinical Medicine, University of Turku, Turku, Finland.
  • Silver E; Department of Radiology, Turku University Hospital, Turku, Finland.
  • Copeland A; FinnBrain Birth Cohort Study, Turku Brain and Mind Center, Department of Clinical Medicine, University of Turku, Turku, Finland.
  • Pulli EP; FinnBrain Birth Cohort Study, Turku Brain and Mind Center, Department of Clinical Medicine, University of Turku, Turku, Finland.
  • Lewis JD; FinnBrain Birth Cohort Study, Turku Brain and Mind Center, Department of Clinical Medicine, University of Turku, Turku, Finland.
  • Saukko E; Montreal Neurological Institute, McGill University, Montreal, Canada.
  • Shulist SJ; Department of Radiology, Turku University Hospital, Turku, Finland.
  • Saunavaara J; FinnBrain Birth Cohort Study, Turku Brain and Mind Center, Department of Clinical Medicine, University of Turku, Turku, Finland.
  • Parkkola R; Department of Medical Physics, Turku University Hospital and University of Turku, Turku, Finland.
  • Lähdesmäki T; FinnBrain Birth Cohort Study, Turku Brain and Mind Center, Department of Clinical Medicine, University of Turku, Turku, Finland.
  • Karlsson L; Department of Radiology, Turku University Hospital, Turku, Finland.
  • Karlsson H; FinnBrain Birth Cohort Study, Turku Brain and Mind Center, Department of Clinical Medicine, University of Turku, Turku, Finland.
  • Tuulari JJ; Department of Pediatric Neurology, Turku University Hospital, University of Turku, Turku, Finland.
Hum Brain Mapp ; 44(7): 2712-2725, 2023 05.
Article em En | MEDLINE | ID: mdl-36946076
The rapid white matter (WM) maturation of first years of life is followed by slower yet long-lasting development, accompanied by learning of more elaborate skills. By the age of 5 years, behavioural and cognitive differences between females and males, and functions associated with brain lateralization such as language skills are appearing. Diffusion tensor imaging (DTI) can be used to quantify fractional anisotropy (FA) within the WM and increasing values correspond to advancing brain development. To investigate the normal features of WM development during early childhood, we gathered a DTI data set of 166 healthy infants (mean 3.8 wk, range 2-5 wk; 89 males; born on gestational week 36 or later) and 144 healthy children (mean 5.4 years, range 5.1-5.8 years; 76 males). The sex differences, lateralization patterns and age-dependent changes were examined using tract-based spatial statistics (TBSS). In 5-year-olds, females showed higher FA in wide-spread regions in the posterior and the temporal WM and more so in the right hemisphere, while sex differences were not detected in infants. Gestational age showed stronger association with FA values compared to age after birth in infants. Additionally, child age at scan associated positively with FA around the age of 5 years in the body of corpus callosum, the connections of which are important especially for sensory and motor functions. Lastly, asymmetry of WM microstructure was detected already in infants, yet significant changes in lateralization pattern seem to occur during early childhood, and in 5-year-olds the pattern already resembles adult-like WM asymmetry.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Substância Branca Idioma: En Ano de publicação: 2023 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Substância Branca Idioma: En Ano de publicação: 2023 Tipo de documento: Article