DNA origami presenting the receptor binding domain of SARS-CoV-2 elicit robust protective immune response.
Commun Biol
; 6(1): 308, 2023 03 23.
Article
em En
| MEDLINE
| ID: mdl-36959304
ABSTRACT
Effective and safe vaccines are invaluable tools in the arsenal to fight infectious diseases. The rapid spreading of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) responsible for the coronavirus disease 2019 pandemic has highlighted the need to develop methods for rapid and efficient vaccine development. DNA origami nanoparticles (DNA-NPs) presenting multiple antigens in prescribed nanoscale patterns have recently emerged as a safe, efficient, and easily scalable alternative for rational design of vaccines. Here, we are leveraging the unique properties of these DNA-NPs and demonstrate that precisely patterning ten copies of a reconstituted trimer of the receptor binding domain (RBD) of SARS-CoV-2 along with CpG adjuvants on the DNA-NPs is able to elicit a robust protective immunity against SARS-CoV-2 in a mouse model. Our results demonstrate the potential of our DNA-NP-based approach for developing safe and effective nanovaccines against infectious diseases with prolonged antibody response and effective protection in the context of a viral challenge.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Vacinas Virais
/
COVID-19
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article