Bcat1 is controlled by Tsc2/mTORC1 pathway at expression levels and its deficiency together with Bcat2 inactivation suppresses the growth of a Tsc2<sup>-/-</sup> tumor cell line.

Nishikawa, Keiko; Mezawa, Yoshihiro; Kobayashi, Toshiyuki

Bcat1 is controlled by Tsc2/mTORC1 pathway at expression levels and its deficiency together with Bcat2 inactivation suppresses the growth of a Tsc2^-/- tumor cell line.

Nishikawa, Keiko; Mezawa, Yoshihiro; Kobayashi, Toshiyuki.

Afiliação

Nishikawa K; Department of Molecular Pathogenesis, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan.
Mezawa Y; Department of Molecular Pathogenesis, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan.
Kobayashi T; Department of Molecular Pathogenesis, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan.

Genes Cells ; 28(6): 447-456, 2023 Jun.

Article em En | MEDLINE | ID: mdl-36965015

Assuntos

Esclerose Tuberosa; Camundongos; Animais; Esclerose Tuberosa/metabolismo; Esclerose Tuberosa/patologia; Alvo Mecanístico do Complexo 1 de Rapamicina/metabolismo; Proteínas Supressoras de Tumor/genética; Proteínas Supressoras de Tumor/metabolismo; Linhagem Celular Tumoral; Sirolimo/farmacologia; Transaminases

Palavras-chave

BCAA; Bcat1; Bcat2; mTORC1; tuberous sclerosis complex

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Esclerose Tuberosa Idioma: En Ano de publicação: 2023 Tipo de documento: Article

Texto completo

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Esclerose Tuberosa Idioma: En Ano de publicação: 2023 Tipo de documento: Article