Tumor-targeted superantigens produce curative tumor immunity with induction of memory and demonstrated antigen spreading.

Azulay, Meir; Shahar, Michal; Shany, Eitan; Elbaz, Eti; Lifshits, Sveta; Törngren, Marie; Friedmann, Adam; Kramer, Robert; Hedlund, Gunnar

Azulay, Meir; Shahar, Michal; Shany, Eitan; Elbaz, Eti; Lifshits, Sveta; Törngren, Marie; Friedmann, Adam; Kramer, Robert; Hedlund, Gunnar.

Afiliação

Azulay M; NeoTX Therapeutics LTD, Rehovot, Israel. meir@neotx.com.
Shahar M; NeoTX Therapeutics LTD, Rehovot, Israel.
Shany E; NeoTX Therapeutics LTD, Rehovot, Israel.
Elbaz E; NeoTX Therapeutics LTD, Rehovot, Israel.
Lifshits S; NeoTX Therapeutics LTD, Rehovot, Israel.
Törngren M; Active Biotech AB, Lund, Sweden.
Friedmann A; NeoTX Therapeutics LTD, Rehovot, Israel.
Kramer R; Department of Genetics, The Hebrew University, Jerusalem, Israel.
Hedlund G; NeoTX Therapeutics LTD, Rehovot, Israel.

J Transl Med ; 21(1): 222, 2023 03 26.

Article em En | MEDLINE | ID: mdl-36967382

Assuntos

Antineoplásicos; Neoplasias; Humanos; Animais; Camundongos; Superantígenos/uso terapêutico; Linfócitos T; Neoplasias/patologia; Antineoplásicos/farmacologia; Imunoterapia; Microambiente Tumoral; Linhagem Celular Tumoral

Palavras-chave

Antigen-presenting cells; Immune checkpoint inhibitors; Immunotherapy; Memory T lymphocytes; Naptumomab estafenatox; Programmed cell death 1 receptor; Superantigens; T-cell receptors; Tumor infiltrating lymphocyte

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias / Antineoplásicos Idioma: En Ano de publicação: 2023 Tipo de documento: Article

Texto completo

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XML

PubMed Links

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias / Antineoplásicos Idioma: En Ano de publicação: 2023 Tipo de documento: Article