Synthesis of gallic acid amide derivatives containing 1,3,4-thiadiazole and their inhibitory activity on Vibrio harveyi.

Chen, Chao; Wu, Yuyu; Su, Ziqin; Qiu, Min; Gao, Tiantian; Liang, Xinwen; Wu, Qinkuai; Jiang, Kaijun; Liu, Weiwei

Chen, Chao; Wu, Yuyu; Su, Ziqin; Qiu, Min; Gao, Tiantian; Liang, Xinwen; Wu, Qinkuai; Jiang, Kaijun; Liu, Weiwei.

Afiliação

Chen C; Jiangsu Key Laboratory of Marine Bioresources and Environment, Co-Innovation Center of Jiangsu Marine Bio-Industry Technology, Jiangsu Ocean University, Lianyungang, China/Jiangsu Key Laboratory of Marine Biotechnology, Jiangsu Key Laboratory of Marine Pharmaceutical Compound Screening, College of p
Wu Y; Jiangsu Key Laboratory of Marine Bioresources and Environment, Co-Innovation Center of Jiangsu Marine Bio-Industry Technology, Jiangsu Ocean University, Lianyungang, China/Jiangsu Key Laboratory of Marine Biotechnology, Jiangsu Key Laboratory of Marine Pharmaceutical Compound Screening, College of p
Su Z; Jiangsu Key Laboratory of Marine Bioresources and Environment, Co-Innovation Center of Jiangsu Marine Bio-Industry Technology, Jiangsu Ocean University, Lianyungang, China/Jiangsu Key Laboratory of Marine Biotechnology, Jiangsu Key Laboratory of Marine Pharmaceutical Compound Screening, College of p
Qiu M; Jiangsu Key Laboratory of Marine Bioresources and Environment, Co-Innovation Center of Jiangsu Marine Bio-Industry Technology, Jiangsu Ocean University, Lianyungang, China/Jiangsu Key Laboratory of Marine Biotechnology, Jiangsu Key Laboratory of Marine Pharmaceutical Compound Screening, College of p
Gao T; Jiangsu Key Laboratory of Marine Bioresources and Environment, Co-Innovation Center of Jiangsu Marine Bio-Industry Technology, Jiangsu Ocean University, Lianyungang, China/Jiangsu Key Laboratory of Marine Biotechnology, Jiangsu Key Laboratory of Marine Pharmaceutical Compound Screening, College of p
Liang X; Jiangsu Key Laboratory of Marine Bioresources and Environment, Co-Innovation Center of Jiangsu Marine Bio-Industry Technology, Jiangsu Ocean University, Lianyungang, China/Jiangsu Key Laboratory of Marine Biotechnology, Jiangsu Key Laboratory of Marine Pharmaceutical Compound Screening, College of p
Wu Q; Jiangsu Key Laboratory of Marine Bioresources and Environment, Co-Innovation Center of Jiangsu Marine Bio-Industry Technology, Jiangsu Ocean University, Lianyungang, China/Jiangsu Key Laboratory of Marine Biotechnology, Jiangsu Key Laboratory of Marine Pharmaceutical Compound Screening, College of p
Jiang K; Jiangsu Key Laboratory of Marine Bioresources and Environment, Co-Innovation Center of Jiangsu Marine Bio-Industry Technology, Jiangsu Ocean University, Lianyungang, China/Jiangsu Key Laboratory of Marine Biotechnology, Jiangsu Key Laboratory of Marine Pharmaceutical Compound Screening, College of p
Liu W; Jiangsu Key Laboratory of Marine Bioresources and Environment, Co-Innovation Center of Jiangsu Marine Bio-Industry Technology, Jiangsu Ocean University, Lianyungang, China/Jiangsu Key Laboratory of Marine Biotechnology, Jiangsu Key Laboratory of Marine Pharmaceutical Compound Screening, College of p

Pak J Pharm Sci ; 36(1): 99-102, 2023 Jan.

Article em En | MEDLINE | ID: mdl-36967502

RESUMO

Using Gallic acid as raw material, 1-(substituted aromatic acyl)-4-(3,4,5-trihydroxybenzoyl) thiosemicarbazone was prepared by a two-step reaction and a series of brand-new gallic acid amide derivatives that contained 1,3,4-thiadiazole were synthesized by cyclic reaction. The newly prepared compounds' Vibrio harveyi inhibition activities were evaluated. The results indicated that all compounds showed different degree of inhibitory activity on Vibrio harveyi. Among them, the best inhibition effect was shown by compound 5b and its minimum inhibitory concentration (MIC) was 0.0313mg/mL.

Assuntos

Ácido Gálico; Vibrio; Ácido Gálico/farmacologia; Amidas/farmacologia

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