Development and Characterization of Mouse-Specific Anti-Tau Monoclonal Antibodies: Relevance for Analysis of Murine Tau in Cerebrospinal Fluid.

Rodrigues Martins, Dina; Vandermeeren, Marc; Van Kolen, Kristof; Brepoels, Eddy; Borgers, Marianne; Wintmolders, Cindy; Delay, Charlotte; Bottelbergs, Astrid; Mercken, Marc; Theunis, Clara

Rodrigues Martins, Dina; Vandermeeren, Marc; Van Kolen, Kristof; Brepoels, Eddy; Borgers, Marianne; Wintmolders, Cindy; Delay, Charlotte; Bottelbergs, Astrid; Mercken, Marc; Theunis, Clara.

Afiliação

Rodrigues Martins D; Neuroscience Department, Janssen Research & Development, Janssen Pharmaceutica NV, Beerse, Belgium.
Vandermeeren M; Neuroscience Department, Janssen Research & Development, Janssen Pharmaceutica NV, Beerse, Belgium.
Van Kolen K; Neuroscience Department, Janssen Research & Development, Janssen Pharmaceutica NV, Beerse, Belgium.
Brepoels E; Biologics Research, Janssen Research & Development, Janssen Pharmaceutica NV, Beerse, Belgium.
Borgers M; Neuroscience Department, Janssen Research & Development, Janssen Pharmaceutica NV, Beerse, Belgium.
Wintmolders C; Neuroscience Department, Janssen Research & Development, Janssen Pharmaceutica NV, Beerse, Belgium.
Delay C; Neuroscience Department, Janssen Research & Development, Janssen Pharmaceutica NV, Beerse, Belgium.
Bottelbergs A; Neuroscience Department, Janssen Research & Development, Janssen Pharmaceutica NV, Beerse, Belgium.
Mercken M; Neuroscience Department, Janssen Research & Development, Janssen Pharmaceutica NV, Beerse, Belgium.
Theunis C; Neuroscience Department, Janssen Research & Development, Janssen Pharmaceutica NV, Beerse, Belgium.

J Alzheimers Dis ; 93(1): 151-167, 2023.

Article em En | MEDLINE | ID: mdl-36970909

Assuntos

Doença de Alzheimer; Tauopatias; Camundongos; Humanos; Animais; Proteínas tau/metabolismo; Tauopatias/patologia; Doença de Alzheimer/patologia; Camundongos Transgênicos; Modelos Animais de Doenças; Anticorpos Monoclonais; Encéfalo/patologia

Palavras-chave

Antibodies; assay development; cerebrospinal fluid; murine tau; tau aggregation

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Tauopatias / Doença de Alzheimer Idioma: En Ano de publicação: 2023 Tipo de documento: Article

Texto completo

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XML

PubMed Links

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Tauopatias / Doença de Alzheimer Idioma: En Ano de publicação: 2023 Tipo de documento: Article