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APOE and immunity: Research highlights.
Kloske, Courtney M; Barnum, Christopher J; Batista, Andre F; Bradshaw, Elizabeth M; Brickman, Adam M; Bu, Guojun; Dennison, Jessica; Gearon, Mary D; Goate, Alison M; Haass, Christian; Heneka, Michael T; Hu, William T; Huggins, Lenique K L; Jones, Nahdia S; Koldamova, Radosveta; Lemere, Cynthia A; Liddelow, Shane A; Marcora, Edoardo; Marsh, Samuel E; Nielsen, Henrietta M; Petersen, Kellen K; Petersen, Melissa; Piña-Escudero, Stefanie D; Qiu, Wei Qiao; Quiroz, Yakeel T; Reiman, Eric; Sexton, Claire; Tansey, Malú Gámez; Tcw, Julia; Teunissen, Charlotte E; Tijms, Betty M; van der Kant, Rik; Wallings, Rebecca; Weninger, Stacie C; Wharton, Whitney; Wilcock, Donna M; Wishard, Tyler James; Worley, Susan L; Zetterberg, Henrik; Carrillo, Maria C.
Afiliação
  • Kloske CM; Alzheimer's Association, Chicago, Illinois, USA.
  • Barnum CJ; INmune Bio, Inc, La Jolla, California, USA.
  • Batista AF; Department of Neurology, Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Boston, Massachusetts, USA.
  • Bradshaw EM; Departments of Neurology, Harvard Medical School, Boston, Massachusetts, USA.
  • Brickman AM; Department of Neurology, Columbia University Irving Medical Center, New York, New York, USA.
  • Bu G; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, G.H. Sergievsky Center, and Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York, USA.
  • Dennison J; Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, USA.
  • Gearon MD; Department of Psychiatry & Behavioral Sciences, University of Miami Miller School of Medicine, Miami, Florida, USA.
  • Goate AM; Department of Physiology, University of Kentucky, Lexington, Kentucky, USA.
  • Haass C; Department of Genetics & Genomic Sciences, Ronald M. Loeb Center for Alzheimer's disease, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
  • Heneka MT; Metabolic Biochemistry, Biomedical Center (BMC), Faculty of Medicine, LMU Munich, Munich, Germany.
  • Hu WT; German Center for Neurodegenerative Diseases (DZNE), Munich, Germany 3 Munich Cluster for Systems Neurology (SyNergy), Munich, Germany.
  • Huggins LKL; Luxembourg Centre for Systems Biomedicine (LCSB) University of Luxembourg, Esch-sur-Alzette, Luxembourg.
  • Jones NS; Department of Neurology, Rutgers-Robert Wood Johnson Medical School and Center for Healthy Aging, Rutgers Institute for Health, Health Care Policy, and Aging Research, New Brunswick, New Jersey, USA.
  • Koldamova R; Department of Biology, Duke University, Durham, North Carolina, USA.
  • Lemere CA; Yale School of Medicine, New Haven, Connecticut, USA.
  • Liddelow SA; Interdisciplinary Program in Neuroscience, Georgetown University, Washington, District of Columbia, USA.
  • Marcora E; EOH, School of Public Health University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
  • Marsh SE; Department of Neurology, Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Boston, Massachusetts, USA.
  • Nielsen HM; Departments of Neurology, Harvard Medical School, Boston, Massachusetts, USA.
  • Petersen KK; Neuroscience Institute and Departments of Neuroscience & Physiology and of Ophthalmology, NYU Grossman School of Medicine, New York, New York, USA.
  • Petersen M; Ronald M. Loeb Center for Alzheimer's disease, Dept. of Genetics & Genomic Sciences, Dept. of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
  • Piña-Escudero SD; F.M. Kirby Neurobiology Center, Boston Children's Hospital, Boston, Massachusetts, USA.
  • Qiu WQ; Harvard Medical School, Boston, Massachusetts, USA.
  • Quiroz YT; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
  • Reiman E; Department of Biochemistry and Biophysics, Stockholm University, Stockholm, Sweden.
  • Sexton C; The Saul R. Korey Department of Neurology, Albert Einstein College of Medicine, Bronx, New York, USA.
  • Tansey MG; Department of Family Medicine, Institute of Translational Research, University of North Texas Health Science Center, Fort Worth, Texas, USA.
  • Tcw J; Global Brain Health Institute, Department of Neurology, University of California, San Francisco, California, USA.
  • Teunissen CE; Boston University School of Medicine, Boston, Massachusetts, USA.
  • Tijms BM; Departments of Psychiatry and Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
  • van der Kant R; Banner Alzheimer's Institute, Phoenix, Arizona, USA.
  • Wallings R; Banner Research, Phoenix, Arizona, USA.
  • Weninger SC; Alzheimer's Association, Chicago, Illinois, USA.
  • Wharton W; Department of Neuroscience and Center for Translational Research in Neurodegenerative Disease, College of Medicine, University of Florida, Gainesville, Florida, USA.
  • Wilcock DM; Department of Pharmacology & Experimental Therapeutics, Boston University School of Medicine, Boston, Massachusetts, USA.
  • Wishard TJ; Neurochemistry Laboratory, Clinical Chemistry department, Amsterdam Neuroscience, Program Neurodegeneration, Amsterdam University Medical Centers, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
  • Worley SL; Alzheimer Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc, Amsterdam, The Netherlands.
  • Zetterberg H; Amsterdam Neuroscience, Neurodegeneration, Amsterdam, The Netherlands.
  • Carrillo MC; Department of Functional Genomics, Center for Neurogenomics and Cognitive Research (CNCR), VU University Amsterdam, Amsterdam, The Netherlands.
Alzheimers Dement ; 19(6): 2677-2696, 2023 06.
Article em En | MEDLINE | ID: mdl-36975090
ABSTRACT

INTRODUCTION:

At the Alzheimer's Association's APOE and Immunity virtual conference, held in October 2021, leading neuroscience experts shared recent research advances on and inspiring insights into the various roles that both the apolipoprotein E gene (APOE) and facets of immunity play in neurodegenerative diseases, including Alzheimer's disease and other dementias.

METHODS:

The meeting brought together more than 1200 registered attendees from 62 different countries, representing the realms of academia and industry.

RESULTS:

During the 4-day meeting, presenters illuminated aspects of the cross-talk between APOE and immunity, with a focus on the roles of microglia, triggering receptor expressed on myeloid cells 2 (TREM2), and components of inflammation (e.g., tumor necrosis factor α [TNFα]).

DISCUSSION:

This manuscript emphasizes the importance of diversity in current and future research and presents an integrated view of innate immune functions in Alzheimer's disease as well as related promising directions in drug development.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doença de Alzheimer Idioma: En Ano de publicação: 2023 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doença de Alzheimer Idioma: En Ano de publicação: 2023 Tipo de documento: Article