Differential Binding and Conformational Dynamics of Tau Microtubule-Binding Repeats with a Preformed Amyloid-ß Fibril Seed.

Song, Zhiyuan; Gatch, Adam J; Sun, Yunxiang; Ding, Feng

Song, Zhiyuan; Gatch, Adam J; Sun, Yunxiang; Ding, Feng.

Afiliação

Song Z; Department of Physics and Astronomy, Clemson University, Clemson, South Carolina 29634, United States.
Gatch AJ; Department of Physics and Astronomy, Clemson University, Clemson, South Carolina 29634, United States.
Sun Y; Department of Genetics and Biochemistry, Clemson University, Clemson, South Carolina 29634, United States.
Ding F; Department of Physics and Astronomy, Clemson University, Clemson, South Carolina 29634, United States.

ACS Chem Neurosci ; 14(7): 1321-1330, 2023 04 05.

Article em En | MEDLINE | ID: mdl-36975100

Assuntos

Doença de Alzheimer; Proteínas tau; Humanos; Proteínas tau/metabolismo; Amiloide; Placa Amiloide/patologia; Doença de Alzheimer/metabolismo; Peptídeos beta-Amiloides/metabolismo; Microtúbulos/metabolismo

Palavras-chave

Alzheimer's disease; Aß fibril seed; cross-seeding; microtubule-binding repeats of tau; neurofibrillary tangles

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteínas tau / Doença de Alzheimer Idioma: En Ano de publicação: 2023 Tipo de documento: Article

Texto completo

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XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteínas tau / Doença de Alzheimer Idioma: En Ano de publicação: 2023 Tipo de documento: Article