Stunning of neutrophils accounts for the anti-inflammatory effects of clodronate liposomes.
J Exp Med
; 220(6)2023 06 05.
Article
em En
| MEDLINE
| ID: mdl-36976180
ABSTRACT
Clodronate liposomes (Clo-Lip) have been widely used to deplete mononuclear phagocytes (MoPh) to study the function of these cells in vivo. Here, we revisited the effects of Clo-Lip together with genetic models of MoPh deficiency, revealing that Clo-Lip exert their anti-inflammatory effects independent of MoPh. Notably, not only MoPh but also polymorphonuclear neutrophils (PMN) ingested Clo-Lip in vivo, which resulted in their functional arrest. Adoptive transfer of PMN, but not of MoPh, reversed the anti-inflammatory effects of Clo-Lip treatment, indicating that stunning of PMN rather than depletion of MoPh accounts for the anti-inflammatory effects of Clo-Lip in vivo. Our data highlight the need for a critical revision of the current literature on the role of MoPh in inflammation.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Ácido Clodrônico
/
Lipossomos
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article