Expanding the Chemical Space of Arsenicin A-C Related Polyarsenicals and Evaluation of Some Analogs as Inhibitors of Glioblastoma Stem Cell Growth.

Vigna, Jacopo; Sighel, Denise; Rosatti, Emanuele Filiberto; Defant, Andrea; Pancher, Michael; Sidarovich, Viktoryia; Quattrone, Alessandro; Mancini, Ines

Vigna, Jacopo; Sighel, Denise; Rosatti, Emanuele Filiberto; Defant, Andrea; Pancher, Michael; Sidarovich, Viktoryia; Quattrone, Alessandro; Mancini, Ines.

Afiliação

Vigna J; Laboratory of Bioorganic Chemistry, Department of Physics, University of Trento, Via Sommarive 14, 38123 Trento, Italy.
Sighel D; Laboratory of Translational Genomics, Department of Cellular, Computational and Integrative Biology (CIBIO), University of Trento, Via Sommarive 9, 38123 Trento, Italy.
Rosatti EF; Laboratory of Translational Genomics, Department of Cellular, Computational and Integrative Biology (CIBIO), University of Trento, Via Sommarive 9, 38123 Trento, Italy.
Defant A; Laboratory of Bioorganic Chemistry, Department of Physics, University of Trento, Via Sommarive 14, 38123 Trento, Italy.
Pancher M; High Throughput Screening (HTS) and Validation Core Facility, Department of Cellular, Computational and Integrative Biology (CIBIO), University of Trento, Via Sommarive 9, 38123 Trento, Italy.
Sidarovich V; High Throughput Screening (HTS) and Validation Core Facility, Department of Cellular, Computational and Integrative Biology (CIBIO), University of Trento, Via Sommarive 9, 38123 Trento, Italy.
Quattrone A; Laboratory of Translational Genomics, Department of Cellular, Computational and Integrative Biology (CIBIO), University of Trento, Via Sommarive 9, 38123 Trento, Italy.
Mancini I; Laboratory of Bioorganic Chemistry, Department of Physics, University of Trento, Via Sommarive 14, 38123 Trento, Italy.

Mar Drugs ; 21(3)2023 Mar 17.

Article em En | MEDLINE | ID: mdl-36976235

Assuntos

Adamantano; Neoplasias Encefálicas; Glioblastoma; Humanos; Trióxido de Arsênio/farmacologia; Trióxido de Arsênio/uso terapêutico; Glioblastoma/tratamento farmacológico; Glioblastoma/patologia; Células-Tronco; Adamantano/uso terapêutico; Linhagem Celular Tumoral; Neoplasias Encefálicas/tratamento farmacológico

Palavras-chave

ADME prediction; As-S cage; antitumor; arsenic trioxide; calculated NMR spectrum; cancer stem cell; glioblastoma; hypoxia; marine metabolite; polyarsenical

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Encefálicas / Adamantano / Glioblastoma Idioma: En Ano de publicação: 2023 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Encefálicas / Adamantano / Glioblastoma Idioma: En Ano de publicação: 2023 Tipo de documento: Article