SARS-CoV-2 Main Protease Targets Host Selenoproteins and Glutathione Biosynthesis for Knockdown via Proteolysis, Potentially Disrupting the Thioredoxin and Glutaredoxin Redox Cycles.

Gallardo, Ignacio A; Todd, Daniel A; Lima, Stella T; Chekan, Jonathan R; Chiu, Norman H; Taylor, Ethan Will

Gallardo, Ignacio A; Todd, Daniel A; Lima, Stella T; Chekan, Jonathan R; Chiu, Norman H; Taylor, Ethan Will.

Afiliação

Gallardo IA; Department of Chemistry and Biochemistry, University of North Carolina Greensboro, Greensboro, NC 27403, USA.
Todd DA; Department of Chemistry and Biochemistry, University of North Carolina Greensboro, Greensboro, NC 27403, USA.
Lima ST; Department of Chemistry and Biochemistry, University of North Carolina Greensboro, Greensboro, NC 27403, USA.
Chekan JR; Department of Chemistry and Biochemistry, University of North Carolina Greensboro, Greensboro, NC 27403, USA.
Chiu NH; Department of Chemistry and Biochemistry, University of North Carolina Greensboro, Greensboro, NC 27403, USA.
Taylor EW; Department of Chemistry and Biochemistry, University of North Carolina Greensboro, Greensboro, NC 27403, USA.

Antioxidants (Basel) ; 12(3)2023 Feb 23.

Article em En | MEDLINE | ID: mdl-36978807