Identification of Potential Inhibitors for the Treatment of Alkaptonuria Using an Integrated In Silico Computational Strategy.

Zaib, Sumera; Rana, Nehal; Hussain, Nadia; Ogaly, Hanan A; Dera, Ayed A; Khan, Imtiaz

Zaib, Sumera; Rana, Nehal; Hussain, Nadia; Ogaly, Hanan A; Dera, Ayed A; Khan, Imtiaz.

Afiliação

Zaib S; Department of Basic and Applied Chemistry, Faculty of Science and Technology, University of Central Punjab, Lahore 54590, Pakistan.
Rana N; Department of Basic and Applied Chemistry, Faculty of Science and Technology, University of Central Punjab, Lahore 54590, Pakistan.
Hussain N; Department of Pharmaceutical Sciences, College of Pharmacy, Al Ain University, Al Ain P.O. Box 64141, United Arab Emirates.
Ogaly HA; AAU Health and Biomedical Research Center, Al Ain University, Abu Dhabi P.O. Box 144534, United Arab Emirates.
Dera AA; Chemistry Department, College of Science, King Khalid University, Abha 61421, Saudi Arabia.
Khan I; Biochemistry and Molecular Biology Department, Faculty of Veterinary Medicine, Cairo University, Giza 12211, Egypt.

Molecules ; 28(6)2023 Mar 14.

Article em En | MEDLINE | ID: mdl-36985595

Assuntos

4-Hidroxifenilpiruvato Dioxigenase; Alcaptonúria; Ocronose; Humanos; Alcaptonúria/tratamento farmacológico; Alcaptonúria/genética; Alcaptonúria/metabolismo; Simulação de Acoplamento Molecular; Ocronose/tratamento farmacológico; Ácido Homogentísico/metabolismo

Palavras-chave

4-hydroxyphenylpyruvate dioxygenase; ReCore; alkaptonuria; homogentisate dioxygenase; nitisinone

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Alcaptonúria / 4-Hidroxifenilpiruvato Dioxigenase / Ocronose Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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