Use of In Vitro Dynamic Colon Model (DCM) to Inform a Physiologically Based Biopharmaceutic Model (PBBM) to Predict the In Vivo Performance of a Modified-Release Formulation of Theophylline.

Stamatopoulos, Konstantinos; O'Farrell, Connor; Simmons, Mark J H; Batchelor, Hannah K; Mistry, Nena

Stamatopoulos, Konstantinos; O'Farrell, Connor; Simmons, Mark J H; Batchelor, Hannah K; Mistry, Nena.

Afiliação

Stamatopoulos K; Biopharmaceutics, DPD, MDS, GSK, David Jack Centre, Park Road, Ware SG12 0DP, UK.
O'Farrell C; School of Chemical Engineering, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK.
Simmons MJH; School of Chemical Engineering, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK.
Batchelor HK; Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, 161 Cathedral Street, Glasgow G4 0RE, UK.
Mistry N; Biopharmaceutics, DPD, MDS, GSK, David Jack Centre, Park Road, Ware SG12 0DP, UK.

Pharmaceutics ; 15(3)2023 Mar 09.

Article em En | MEDLINE | ID: mdl-36986743

Palavras-chave

Dynamic Colon Model (DCM); PBBM; PBPK; SimCyp®; USP II; dissolution testing; in silico modelling; in vitro model; modified release (MR); pharmacokinetics; theophylline

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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2023 Tipo de documento: Article