Food-Induced Anaphylaxis: Data From the European Anaphylaxis Registry.
J Allergy Clin Immunol Pract
; 11(7): 2069-2079.e7, 2023 07.
Article
em En
| MEDLINE
| ID: mdl-36990430
ABSTRACT
BACKGROUND:
Food is one of the most common elicitors of anaphylaxis, with an increasing incidence over recent years.OBJECTIVES:
To characterize elicitor-specific phenotypes and identify factors enhancing the risk or severity of food-induced anaphylaxis (FIA).METHODS:
We analyzed data from the European Anaphylaxis Registry applying an age- and sex-matched analysis of associations (Cramer's V) for single food triggers and calculated odds ratios (ORs) for severe FIA.RESULTS:
We identified 3,427 cases of confirmed FIA showing an age-dependent elicitor ranking (for children peanut, cow's milk, cashew, and hen's egg; and for adults wheat flour, shellfish, hazelnut, and soy). The age- and sex-matched analysis revealed defined symptom patterns for wheat and cashew. Wheat-induced anaphylaxis was more frequently associated with cardiovascular symptoms (75.7%; Cramer's V = 0.28) and cashew-induced anaphylaxis with gastrointestinal symptoms (73.9%; Cramer's V = 0.20). Furthermore, concomitant atopic dermatitis was slightly associated with anaphylaxis to hen's egg (Cramer's V = 0.19) and exercise was strongly associated with anaphylaxis to wheat (Cramer's V = 0.56). Additional factors influencing the severity were alcohol intake in wheat anaphylaxis (OR = 3.23; CI, 1.31-8.83) and exercise in peanut anaphylaxis (OR = 1.78; CI, 1.09-2.95).CONCLUSIONS:
Our data show that FIA is age-dependent. In adults, the range of elicitors inducing FIA is broader. For some elicitors, the severity of FIA seems to be related to the elicitor. These data require confirmation in future studies considering a clear differentiation between augmentation and risk factors in FIA.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Hipersensibilidade Alimentar
/
Anafilaxia
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article