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Hypothalamic melanin-concentrating hormone neurons integrate food-motivated appetitive and consummatory processes in rats.
Subramanian, Keshav S; Lauer, Logan Tierno; Hayes, Anna M R; Décarie-Spain, Léa; McBurnett, Kara; Nourbash, Anna C; Donohue, Kristen N; Kao, Alicia E; Bashaw, Alexander G; Burdakov, Denis; Noble, Emily E; Schier, Lindsey A; Kanoski, Scott E.
Afiliação
  • Subramanian KS; Human and Evolutionary Biology Section, Department of Biological Sciences, Dornsife College of Letters, Arts and Sciences, University of Southern California, Los Angeles, California, USA.
  • Lauer LT; Neuroscience Graduate Program, University of Southern California, Los Angeles, California, USA.
  • Hayes AMR; Human and Evolutionary Biology Section, Department of Biological Sciences, Dornsife College of Letters, Arts and Sciences, University of Southern California, Los Angeles, California, USA.
  • Décarie-Spain L; Human and Evolutionary Biology Section, Department of Biological Sciences, Dornsife College of Letters, Arts and Sciences, University of Southern California, Los Angeles, California, USA.
  • McBurnett K; Human and Evolutionary Biology Section, Department of Biological Sciences, Dornsife College of Letters, Arts and Sciences, University of Southern California, Los Angeles, California, USA.
  • Nourbash AC; Human and Evolutionary Biology Section, Department of Biological Sciences, Dornsife College of Letters, Arts and Sciences, University of Southern California, Los Angeles, California, USA.
  • Donohue KN; Human and Evolutionary Biology Section, Department of Biological Sciences, Dornsife College of Letters, Arts and Sciences, University of Southern California, Los Angeles, California, USA.
  • Kao AE; Human and Evolutionary Biology Section, Department of Biological Sciences, Dornsife College of Letters, Arts and Sciences, University of Southern California, Los Angeles, California, USA.
  • Bashaw AG; Human and Evolutionary Biology Section, Department of Biological Sciences, Dornsife College of Letters, Arts and Sciences, University of Southern California, Los Angeles, California, USA.
  • Burdakov D; Human and Evolutionary Biology Section, Department of Biological Sciences, Dornsife College of Letters, Arts and Sciences, University of Southern California, Los Angeles, California, USA.
  • Noble EE; Neuroscience Graduate Program, University of Southern California, Los Angeles, California, USA.
  • Schier LA; Department of Health Sciences and Technology, ETH Zurich, Zurich, Switzerland.
  • Kanoski SE; Department of Nutritional Sciences, University of Georgia, Athens, USA.
Nat Commun ; 14(1): 1755, 2023 03 29.
Article em En | MEDLINE | ID: mdl-36990984
ABSTRACT
The lateral hypothalamic area (LHA) integrates homeostatic processes and reward-motivated behaviors. Here we show that LHA neurons that produce melanin-concentrating hormone (MCH) are dynamically responsive to both food-directed appetitive and consummatory processes in male rats. Specifically, results reveal that MCH neuron Ca2+ activity increases in response to both discrete and contextual food-predictive cues and is correlated with food-motivated responses. MCH neuron activity also increases during eating, and this response is highly predictive of caloric consumption and declines throughout a meal, thus supporting a role for MCH neurons in the positive feedback consummatory process known as appetition. These physiological MCH neural responses are functionally relevant as chemogenetic MCH neuron activation promotes appetitive behavioral responses to food-predictive cues and increases meal size. Finally, MCH neuron activation enhances preference for a noncaloric flavor paired with intragastric glucose. Collectively, these data identify a hypothalamic neural population that orchestrates both food-motivated appetitive and intake-promoting consummatory processes.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Hormônios Hipotalâmicos Idioma: En Ano de publicação: 2023 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Hormônios Hipotalâmicos Idioma: En Ano de publicação: 2023 Tipo de documento: Article