Your browser doesn't support javascript.
loading
Interleukin-33 and Soluble ST2 Levels in Infants with Hypoxic-Ischemic Encephalopathy.
Hamano, Hiroki; Takahashi, Kazumasa; Kimura, Sasagu; Matsuguma, Chie; Kaneyasu, Hidenobu; Fujimoto, Yosuke; Ohta, Naoki; Okada, Seigo; Hasegawa, Shunji.
Afiliação
  • Hamano H; Department of Pediatrics, Yamaguchi University Graduate School of Medicine, Yamaguchi, Japan, p53p21@gmail.com.
  • Takahashi K; Department of Pediatrics, Yamaguchi University Graduate School of Medicine, Yamaguchi, Japan.
  • Kimura S; Department of Pediatrics, Yamaguchi University Graduate School of Medicine, Yamaguchi, Japan.
  • Matsuguma C; Division of Neonatology, Yamaguchi Prefectural Grand Medical Center, Yamaguchi, Japan.
  • Kaneyasu H; Department of Pediatrics, Yamaguchi University Graduate School of Medicine, Yamaguchi, Japan.
  • Fujimoto Y; Department of Pediatrics, Yamaguchi University Graduate School of Medicine, Yamaguchi, Japan.
  • Ohta N; Department of Pediatrics, Yamaguchi University Graduate School of Medicine, Yamaguchi, Japan.
  • Okada S; Division of Neonatology, Yamaguchi Prefectural Grand Medical Center, Yamaguchi, Japan.
  • Hasegawa S; Department of Pediatrics, Yamaguchi University Graduate School of Medicine, Yamaguchi, Japan.
Neonatology ; 120(3): 353-362, 2023.
Article em En | MEDLINE | ID: mdl-36996771
INTRODUCTION: Interleukin (IL)-33 and its receptor ST2L play key roles in the IL-33/ST2 signaling pathway. Soluble ST2 (sST2) inhibits the proper function of IL-33. sST2 levels are increased in patients with several neurological diseases, but in infants with hypoxic-ischemic encephalopathy (HIE), IL-33 and sST2 levels have not been studied. This study aimed to investigate whether serum levels of IL-33 and sST2 are useful as biomarkers of HIE severity and prognostic factors for infants with HIE. METHODS: Twenty-three infants with HIE and 16 controls (gestational age ≥36 weeks and ≥1,800 g birth weight) were enrolled in this study. Serum levels of IL-33 and sST2 were measured at <6 h, 1-2, 3, and 7 days of age. Hydrogen-1 magnetic resonance spectroscopy was performed, and ratios of peak integrals of lactate/N-acetylaspartate (Lac/NAA) were calculated as objective indicators of brain damage. RESULTS: In the moderate and severe HIE, serum sST2 concentrations were increased and there was a good correlation between serum sST2 and HIE severity on days 1-2, whereas no variation was observed in serum IL-33. Serum sST2 levels were positively correlated with Lac/NAA ratios (Kendall's rank correlation coefficient = 0.527, p = 0.024), and both sST2 and Lac/NAA ratios were significantly higher in HIE infants with neurological impairment (p = 0.020 and <0.001, respectively). CONCLUSIONS: sST2 may be a useful predictor of severity and later neurological outcomes in infants with HIE. Further investigation is required to elucidate the relationship between the IL-33/ST2 axis and HIE.
Assuntos
Palavras-chave

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Hipóxia-Isquemia Encefálica / Interleucina-33 Idioma: En Ano de publicação: 2023 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Hipóxia-Isquemia Encefálica / Interleucina-33 Idioma: En Ano de publicação: 2023 Tipo de documento: Article