Vitamin D can ameliorate premature ovarian failure by inhibiting neutrophil extracellular traps: A review.
Medicine (Baltimore)
; 102(13): e33417, 2023 Mar 31.
Article
em En
| MEDLINE
| ID: mdl-37000081
ABSTRACT
The etiology of premature ovarian failure (POF) is mainly related to inflammatory diseases, autoimmune diseases, and tumor radiotherapy and chemotherapy; however, its specific pathogenesis has not been clarified. Vitamin D (VD), a fat-soluble vitamin, is an essential steroid hormone in the human body. Neutrophil extracellular traps (NETs) are meshwork structures that are formed when neutrophils are stimulated by inflammation and other factors and are closely associated with autoimmune and inflammatory diseases. Notably, VD inhibits NET formation and intervenes in the development of POF in terms of inflammatory and immune responses, oxidative stress, and tissue fibrosis. Therefore, this study aimed to theorize the relationship between NETs, VD, and POF and provide new ideas and targets for the pathogenesis and clinical treatment of POF.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Menopausa Precoce
/
Insuficiência Ovariana Primária
/
Armadilhas Extracelulares
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article