Blood redistribution preferentially protects vital organs under hypoxic stress in Pelteobagrus vachelli.
Aquat Toxicol
; 258: 106498, 2023 May.
Article
em En
| MEDLINE
| ID: mdl-37001201
ABSTRACT
Blood redistribution occurs in mammals under hypoxia but has not been reported in fish. This study investigated the tissue damage, hypoxia-inducible factor (HIF) activation level, and blood flow changes in the brain, liver, and muscle of Pelteobagrus vachelli during the hypoxia process for normoxia-hypoxia-asphyxia. The results showed that P. vachelli has tissue specificity in response to hypoxic stress. Cerebral blood flow increased with less damage than in the liver and muscle, suggesting that P. vachelli may also have a blood redistribution mechanism in response to hypoxia. It is worth noting that severe hypoxia can lead to a sudden increase in the degree of brain tissue damage. In addition, higher dissolved oxygen levels activate HIF and may have contributed to the reduced damage observed in the brain. This study provides basic data for investigating hypoxic stress in fish.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Fluxo Sanguíneo Regional
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Peixes-Gato
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Estruturas Animais
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Hipóxia
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article