Myeloid-associated differentiation marker is an essential host factor for human parechovirus PeV-A3 entry.
Nat Commun
; 14(1): 1817, 2023 03 31.
Article
em En
| MEDLINE
| ID: mdl-37002207
ABSTRACT
Human parechovirus (PeV-A) is an RNA virus that belongs to the family Picornaviridae and it is currently classified into 19 genotypes. PeV-As usually cause mild illness in children and adults. Among the genotypes, PeV-A3 can cause severe diseases in neonates and young infants, resulting in neurological sequelae and death. In this study, we identify the human myeloid-associated differentiation marker (MYADM) as an essential host factor for the entry of six PeV-As (PeV-A1 to PeV-A6), including PeV-A3. The infection of six PeV-As (PeV-A1 to PeV-A6) to human cells is abolished by knocking out the expression of MYADM. Hamster BHK-21 cells are resistant to PeV-A infection, but the expression of human MYADM in BHK-21 confers PeV-A infection and viral production. Furthermore, VP0 capsid protein of PeV-A3 interacts with one extracellular domain of human MYADM on the cell membrane of BHK-21. The identification of MYADM as an essential entry factor for PeV-As infection is expected to advance our understanding of the pathogenesis of PeV-As.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Picornaviridae
/
Infecções por Picornaviridae
/
Parechovirus
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article