Glycoside constituents of Camellia amplexicaulis and their α-glucosidase inhibitory activity.
Nat Prod Res
; 38(5): 759-767, 2024.
Article
em En
| MEDLINE
| ID: mdl-37005002
ABSTRACT
Four new glycosides, named amplexicosides A-D (1-4), and five known compounds benzyl 2-[ß-D-glucopyranosyl-(1â6)-ß-D-glucopyranosyloxy]-benzoate (5), benzyl 2-neohesperidosyloxy-6-hydroxybenzoate (6), chrysandroside A (7), chrysandroside B (8) and camelliquercetiside C (9) were isolated from the branches and leaves of Camellia amplexicaulis (Pit.) Cohen-Stuart. Their structures were elucidated using HR-ESI-MS and 1D- and 2D-NMR spectra and compared to reported NMR data. All of the isolated compounds were screened in an α-glucosidase assay. Compounds 4, 8, and 9 significantly inhibited α-glucosidase with respective IC50 values of 254.9 ± 4.2, 304.8 ± 11.9 and 228.1 ± 16.4 µM.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Glicosídeos Cardíacos
/
Camellia
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article