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Study protocol of a randomised, double-blind, placebo-controlled, two-arm parallel-group, multi-centre phase 3 pivotal trial to investigate the efficacy and safety of recombinant human alkaline phosphatase for treatment of patients with sepsis-associated acute kidney injury.
Pickkers, Peter; Angus, Derek C; Arend, Jacques; Bellomo, Rinaldo; van den Berg, Erik; Bernholz, Juliane; Bestle, Morten; Broglio, Kristine; Carlsen, Jan; Doig, Christopher J; Ferrer, Ricard; Joannidis, Michael; Francois, Bruno; Doi, Kent; Kellum, John A; Laterre, Pierre-François; Liu, Kathleen; Mehta, Ravindra L; Murray, Patrick T; Ostermann, Marlies; Pettilä, Ville; Richards, Sharon; Young, Paul; Zarbock, Alexander; Kjølbye, Anne Louise.
Afiliação
  • Pickkers P; Intensive Care Medicine, Radboudumc, Nijmegen, The Netherlands peter.pickkers@radboudumc.nl.
  • Angus DC; Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
  • Arend J; AM-Pharma BV, Bunnik, The Netherlands.
  • Bellomo R; Department of Critical Care, The University of Melbourne, Melbourne, Victoria, Australia.
  • van den Berg E; Department of Critical Care, Austin Hospital, Melbourne, Victoria, Australia.
  • Bernholz J; AM-Pharma BV, Bunnik, The Netherlands.
  • Bestle M; AM-Pharma BV, Bunnik, The Netherlands.
  • Broglio K; Department of Anaesthesiology and Intensive care, Nordsjaellands Hospital, Hillerod, Denmark.
  • Carlsen J; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.
  • Doig CJ; Berry Consultants, Austin, Texas, USA.
  • Ferrer R; AM-Pharma BV, Bunnik, The Netherlands.
  • Joannidis M; Department of Critical Care Medicine, University of Calgary Medical Centre, Calgary, Alberta, Canada.
  • Francois B; Intensive Care Department, Universitat Autònoma de Barcelona, Barcelona, Spain.
  • Doi K; Division of Intensive Care and Emergency Medicine, Department of Internal Medicine, Medical University Innsbruck, Innsbruck, Austria.
  • Kellum JA; ICU and Inserm C1C, University of Limoges, Limoges, France.
  • Laterre PF; Emergency and Critical Care Medicine, The University of Tokyo Hospital, Tokyo, Japan.
  • Liu K; Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
  • Mehta RL; Department of Critical Care Medicine, Cliniques Universitaires Saint-Luc, Brussels, Belgium.
  • Murray PT; Divisions of Critical Care Medicine and Nephrology, Departments of Anesthesia and Medicine, University of California San Fransisco, San Francisco, California, USA.
  • Ostermann M; Department of Medicine, University of California, San Diego, California, USA.
  • Pettilä V; School of Medicine, University College Dublin, Dublin, Ireland.
  • Richards S; Department of Critical Care, King's College London, Guy's & St Thomas' Hospital, London, UK.
  • Young P; Division of Intensive Care Medicine, Department of Anesthesiology, Intensive Care and Pain Medicine, Helsingin Yliopisto Laaketieteellinen tiedekunta, Helsinki, Finland.
  • Zarbock A; PHASTAR, London, UK.
  • Kjølbye AL; Intensive Care Unit, Wellington Hospital, Wellington, New Zealand.
BMJ Open ; 13(4): e065613, 2023 04 03.
Article em En | MEDLINE | ID: mdl-37012016
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Sepse / Injúria Renal Aguda / COVID-19 Idioma: En Ano de publicação: 2023 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Sepse / Injúria Renal Aguda / COVID-19 Idioma: En Ano de publicação: 2023 Tipo de documento: Article