Hashimoto's thyroiditis and renal transplant rejection.
J Endocrinol Invest
; 46(10): 2125-2132, 2023 Oct.
Article
em En
| MEDLINE
| ID: mdl-37012521
ABSTRACT
PURPOSE:
Hashimoto's thyroiditis (HT) is a common autoimmune thyroid disorder that can disrupt thyroid function and homeostasis. As HT results from a dysregulated immune system, we hypothesized that these patients might be more susceptible to transplant failure; however, literature on this association is limited. The purpose of this study is to examine the association of HT with the risk of renal transplant failure.METHODS:
We utilized the United States Renal Database System dataset collected from 2005 to 2014 and compared the time from first renal transplant to transplant failure in end-stage renal disease (ESRD) patients with a HT diagnosis to ESRD patients without a HT diagnosis that underwent renal transplant.RESULTS:
A total of 144 ESRD patients had International Classification of Disease-9 claim codes for HT prior to renal transplant, amongst a total cohort of 90,301 renal transplant patients aged 18-100 and meeting criteria. Patients with HT were significantly more likely to be female, white, and to have a diagnosis of cytomegalovirus compared to patients without. ESRD patients with a HT diagnosis that underwent renal transplant had a significantly increased risk of renal transplant failure compared to those ESRD renal transplant patients without an HT diagnosis. There was a significantly increased adjusted hazard ratio for graft failure in patients with a HT diagnosis compared to those without.CONCLUSION:
Thyroid health and HT may play a significant role in the development of the increased risk of renal transplant failure observed in this study. Additional studies are needed to investigate the underlying mechanisms for this association.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Transplante de Rim
/
Doença de Hashimoto
/
Nefropatias
/
Falência Renal Crônica
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article