Rh(III)-catalyzed regioselective versatile indole derivatization: delivering potential of rare ß-(1H-indol-2-yl)-ß-amino acids in one pot.

ABSTRACT

Rh-catalyzed selective C-H functionalization of indoles with two routes was developed an alkenylation-annulation with the addition of KHSO4 and alkenylation-elimination in the presence of CsOAc to the corresponding products, respectively. Notably, one-pot hydrolysis and benzoylation of the annulation products successfully afforded easily separable ß-(1H-indol-2-yl)-ß-amino acid derivatives.