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The prognostic value and biological functions of HFM1 in breast cancer.
Ying, Yingxia; Meng, Yiling; Bian, Lei; Zhang, Meichao; Zhou, Pingting; Zhang, Suning; Wang, Wei; Yao, Yuan; Ren, Qing; Li, Dong.
Afiliação
  • Ying Y; Department of Radiation Oncology, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
  • Meng Y; Department of Radiation Oncology, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
  • Bian L; Department of Radiation Oncology, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
  • Zhang M; Department of Radiation Oncology, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
  • Zhou P; Department of Radiation Oncology, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
  • Zhang S; Department of Emergency, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
  • Wang W; Department of Pathology, Qinghai Provincial People's Hospital, Xining, Qinghai Province, China.
  • Yao Y; Department of Radiation Oncology, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
  • Ren Q; Department of Gynecology & Obstetrics, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
  • Li D; Department of Radiation Oncology, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Epigenomics ; 15(3): 147-166, 2023 02.
Article em En | MEDLINE | ID: mdl-37020390
The role and function of the protein HFM1 in tumors remains unknown. We explored the functions and potential mechanism of HFM1 in breast cancer through several known databases, clinical samples and cell experiments. We found that HFM1 was downregulated in breast cancer with a poor prognosis. HFM1 may mediate ovarian steroidogenesis and participate in tamoxifen resistance of estrogen receptor-positive breast cancer cells. Here we first put forward the relationship between HFM1 and the prognosis of breast cancer, and provided relevant clues for mechanism exploration.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias da Mama / Insuficiência Ovariana Primária Idioma: En Ano de publicação: 2023 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias da Mama / Insuficiência Ovariana Primária Idioma: En Ano de publicação: 2023 Tipo de documento: Article