Synchronously occurring endometrioid carcinomas of the uterine corpus and uterine cervix preceded by different precancerous lesions: A case study and a literature review.
Pathol Res Pract
; 245: 154452, 2023 May.
Article
em En
| MEDLINE
| ID: mdl-37030165
ABSTRACT
The incidence of two synchronous carcinomas originating from the uterine corpus and uterine cervix, both endometrioid subtypes, is exceedingly rare. Herein, we presented synchronous early stage G1 adenocarcinoma of the uterine corpus with cervical G2 endometrioid adenocarcinoma. Although both neoplasms displayed the same histological subtype, they differed significantly according to the histological grading or clinical stage of the disease. Finally, it is worth emphasizing that both tumors were preceded by different precancerous lesions, atypical endometrial hyperplasia (AEH) and foci of endometriosis localized within the uterine cervix. Although AEH is a well-known precancerous condition of endometrioid carcinoma, the mechanisms resulting in the malignant transformation of endometriosis foci to the cervical endometrioid carcinoma are still a matter of controversy. We briefly summarized the impact of different precancerous lesions on the development of synchronous female genital tract neoplasms with the same histotype.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Lesões Pré-Cancerosas
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Neoplasias do Colo do Útero
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Neoplasias do Endométrio
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Carcinoma Endometrioide
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Hiperplasia Endometrial
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Endometriose
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article