Enabling growth-decoupled <i>Komagataella phaffii</i> recombinant protein production based on the methanol-free P<sub>DH</sub> promoter.

Bernat-Camps, Núria; Ebner, Katharina; Schusterbauer, Veronika; Fischer, Jasmin Elgin; Nieto-Taype, Miguel Angel; Valero, Francisco; Glieder, Anton; Garcia-Ortega, Xavier

Enabling growth-decoupled Komagataella phaffii recombinant protein production based on the methanol-free P_DH promoter.

Bernat-Camps, Núria; Ebner, Katharina; Schusterbauer, Veronika; Fischer, Jasmin Elgin; Nieto-Taype, Miguel Angel; Valero, Francisco; Glieder, Anton; Garcia-Ortega, Xavier.

Afiliação

Bernat-Camps N; Department of Chemical, Biological, and Environmental Engineering, School of Engineering, Universitat Autònoma de Barcelona, Bellaterra, Spain.
Ebner K; Austrian Centre of Industrial Biotechnology (ACIB), Graz, Austria.
Schusterbauer V; Bisy GmbH, Hofstaetten, Austria.
Fischer JE; Bisy GmbH, Hofstaetten, Austria.
Nieto-Taype MA; Bisy GmbH, Hofstaetten, Austria.
Valero F; Department of Chemical, Biological, and Environmental Engineering, School of Engineering, Universitat Autònoma de Barcelona, Bellaterra, Spain.
Glieder A; Department of Chemical, Biological, and Environmental Engineering, School of Engineering, Universitat Autònoma de Barcelona, Bellaterra, Spain.
Garcia-Ortega X; Austrian Centre of Industrial Biotechnology (ACIB), Graz, Austria.

Front Bioeng Biotechnol ; 11: 1130583, 2023.

Article em En | MEDLINE | ID: mdl-37034257

Palavras-chave

Komagataella phaffii; PDH; Pichia pastoris; growth-decoupled bioprocess; methanol-free expression system; promoter regulation; recombinant protein production

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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2023 Tipo de documento: Article