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Rubochingosides A - J, labdane-type diterpene glycosides from leaves of Rubus chingii.
Wang, Jianxiong; Xiao, Xiaowu; Zhou, Nian; Zhao, Minmin; Lang, Shuqin; Ren, Qi; Wang, Dong; Fu, Huizheng.
Afiliação
  • Wang J; Jiangxi Institute for Drug Control, NMPA Key Laboratory of Quality Evaluation of Traditional Chinese Patent Medicine, Jiangxi Provincial Engineering Research Center of Drug and Medical Device Quality, Nanchang, Jiangxi, 330029, China; Jiangxi University of Traditional Chinese Medicine, Nanchang, Jia
  • Xiao X; Jiangxi Institute for Drug Control, NMPA Key Laboratory of Quality Evaluation of Traditional Chinese Patent Medicine, Jiangxi Provincial Engineering Research Center of Drug and Medical Device Quality, Nanchang, Jiangxi, 330029, China.
  • Zhou N; Jiangxi Institute for Drug Control, NMPA Key Laboratory of Quality Evaluation of Traditional Chinese Patent Medicine, Jiangxi Provincial Engineering Research Center of Drug and Medical Device Quality, Nanchang, Jiangxi, 330029, China.
  • Zhao M; Jiangxi Institute for Drug Control, NMPA Key Laboratory of Quality Evaluation of Traditional Chinese Patent Medicine, Jiangxi Provincial Engineering Research Center of Drug and Medical Device Quality, Nanchang, Jiangxi, 330029, China; Jiangxi University of Traditional Chinese Medicine, Nanchang, Jia
  • Lang S; Jiangxi Institute for Drug Control, NMPA Key Laboratory of Quality Evaluation of Traditional Chinese Patent Medicine, Jiangxi Provincial Engineering Research Center of Drug and Medical Device Quality, Nanchang, Jiangxi, 330029, China; Jiangxi University of Traditional Chinese Medicine, Nanchang, Jia
  • Ren Q; Jiangxi Institute for Drug Control, NMPA Key Laboratory of Quality Evaluation of Traditional Chinese Patent Medicine, Jiangxi Provincial Engineering Research Center of Drug and Medical Device Quality, Nanchang, Jiangxi, 330029, China.
  • Wang D; Jiangxi University of Traditional Chinese Medicine, Nanchang, Jiangxi, 330004, China; Jiangxi General Institute of Inspection, Testing and Certification, Nanchang, Jiangxi, 330052, China. Electronic address: jxdcwd@126.com.
  • Fu H; Jiangxi Institute for Drug Control, NMPA Key Laboratory of Quality Evaluation of Traditional Chinese Patent Medicine, Jiangxi Provincial Engineering Research Center of Drug and Medical Device Quality, Nanchang, Jiangxi, 330029, China; Jiangxi University of Traditional Chinese Medicine, Nanchang, Jia
Phytochemistry ; 210: 113670, 2023 Jun.
Article em En | MEDLINE | ID: mdl-37037403
ABSTRACT
Ten previously undescribed labdane-type triterpenoids, rubochingosides A - J (1-10), were isolated from the leaves of Rubus chingii Hu. Their structures were elucidated by spectroscopic and chemical methods. The cytotoxicity of all isolated compounds was tested against five human tumor cell lines (Bel-7402, Caski, BGC-823, A2780, and HCT-116). Among them, compounds 4 and 8 showed cytotoxic activities against Bel-7402 and A2780 cells with IC50 values of 10.43 ± 0.51 and 29.03 ± 2.94 µM, respectively; Compound 8 exhibited cytotoxic activities against Bel-7402 and HCT-116 cells with IC50 values of 17.78 ± 1.54 and 26.23 ± 6.14 µM, respectively.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Ovarianas / Diterpenos / Rubus Idioma: En Ano de publicação: 2023 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Ovarianas / Diterpenos / Rubus Idioma: En Ano de publicação: 2023 Tipo de documento: Article